The important role of the histopathologist in clinical trials: challenges and approaches to tackle them.

Histopathology
Elena ProvenzanoAbeer M Shaaban

Abstract

High-quality histopathology is essential for the success of clinical trials. Histopathologists have a detailed understanding of tumour biology and mechanisms of disease, as well as practical knowledge of optimal tissue handling and logistical service requirements for study delivery, such as biomarker evaluation, tissue acquisition and turnaround times. As such, histopathologist input is essential throughout every stage of research and clinical trials, from concept development and study design to trial delivery, analysis and dissemination of results. Patient recruitment to trials takes place among all healthcare settings, meaning that histopathologists make an invaluable contribution to clinical trials as part of their routine day-to-day work that often goes unrecognised. More complex evaluation of surgical specimens in the neoadjuvant setting and ever-expanding minimum data sets add to the workload of every histopathologist, not just academic pathologists in tertiary centres. This is occurring against a backdrop of increasing workload pressures and a worldwide shortage of histopathologists and biomedical scientists. Providing essential histopathology support for trials at grassroots level requires funding for adequate resources...Continue Reading

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Citations

Sep 17, 2020·International Journal of Molecular Sciences·Georg SteinbussMark Kriegsmann
Feb 27, 2021·The Journal of Pathology. Clinical Research·Shujing Jane LimMax Robinson

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