The in vitro antifungal activity of sudanese medicinal plants against Madurella mycetomatis, the eumycetoma major causative agent

PLoS Neglected Tropical Diseases
Hassabelrasoul ElfadilWendy W J van de Sande

Abstract

Eumycetoma is a debilitating chronic inflammatory fungal infection that exists worldwide but it is endemic in many tropical and subtropical regions. The major causative organism is the fungus Madurella mycetomatis. The current treatment of eumycetoma is suboptimal and characterized by low cure rate and high recurrence rates. Hence, an alternative therapy is needed to address this. Here we determined the antifungal activity of seven Sudanese medicinal plant species against Madurella mycetomatis. Of these, only three species; Boswellia papyrifera, Acacia nubica and Nigella sativa, showed some antifungal activity against M. mycetomatis and were further studied. Crude methanol, hexane and defatted methanol extracts of these species were tested for their antifungal activity. B. papyrifera had the highest antifungal activity (MIC50 of 1 ug/ml) and it was further fractionated. The crude methanol and the soluble ethyl acetate fractions of B. papyrifera showed some antifungal activity. The Gas-Liquid-Chromatography hybrid Mass-Spectrophotometer analysis of these two fractions showed the existence of beta-amyrin, beta-amyrone, beta-Sitosterol and stigmatriene. Stigmatriene had the best antifungal activity, compared to other three phytoco...Continue Reading

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Citations

Oct 13, 2015·Journal of Ethnopharmacology·Julia KimondoPeter Njogu
Oct 11, 2017·Medical Mycology·Wendy van de SandeUNKNOWN eumycetoma working group
Jan 16, 2021·Transactions of the Royal Society of Tropical Medicine and Hygiene·Antonella SantonaAhmed Hassan Fahal
Feb 5, 2021·Transactions of the Royal Society of Tropical Medicine and Hygiene·Wendy W J van de Sande
Sep 9, 2021·Clinical Microbiology Reviews·Oyelola AdegboyeClaire Loiseau

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