PMID: 8950309Jan 1, 1996Paper

The in vitro antioxidant activity of trilinolein and other lipid-related natural substances as measured by enhanced chemiluminescence

Life Sciences
Paul ChanC Y Hong

Abstract

There is abundant evidence for the premise that oxygen-derived free radicals (OFR) mediate ischemia/reperfusion injury to the myocardium. OFR scavengers such as superoxide dismutase can effectively reduce damage through lipid peroxidation during ischemia/reperfusion. Enhanced chemiluminescence, which has been used to measure OFR, was used to measure the antioxidant activity of fatty acids (palmitic and linoleic acid) and triglycerides (triolein, tristearin) and natural plant antioxidants (magnolol, catechin, trilinolein). Trilinolein, which has recently been isolated from natural products, as well as the well-known water soluble analogue of vitamin E-Trolox, were used as control. During pretreatment with chemicals, at concentrations of 10(-9) to 10(-7) M, enhanced chemiluminescence of linoleic acid (C 18:2) showed a dose-responsive reduction of OFR with a maximal mean reduction of -31.9% when compared to baseline. A saturated fatty acid such as palmitic acid (C 16:0) showed only relatively weak antioxidant activity at concentrations of 10(-7) to 10(-6) M with a maximum reduction of OFR of- 15.2% only. control chemicals such as trilinolein and Trolox showed significant antioxidant activity. At concentrations between 10(-10) and ...Continue Reading

References

Jan 1, 1978·Infection·T KalagerC O Solberg
Sep 1, 1975·Atherosclerosis·A Keys
Mar 8, 1976·Biochemical and Biophysical Research Communications·R C Allen, L D Loose
Jul 1, 1992·Hypertension·J I Goldhaber, J N Weiss
Feb 9, 1989·The New England Journal of Medicine·S J Weiss
Jul 15, 1988·Experientia·R Van Wijk, D H Schamhart
Jan 1, 1987·Radiation and Environmental Biophysics·M Erben-RussM Saran
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A BoverisB Chance
Aug 1, 1981·Journal of Pharmaceutical Sciences·A M ClarkW S Li
Nov 1, 1994·Thrombosis Research·L J LaiC Y Hong

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Citations

Sep 27, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Hung-Yu YangTzu-Hurng Cheng
Jan 20, 2004·European Journal of Pharmacology·Ju Chi LiuPaul Chan
Aug 7, 2003·Bioorganic & Medicinal Chemistry·Chi-Yuan LiMing-Kuan Hu
Dec 16, 2000·Clinical and Experimental Pharmacology & Physiology·P ChanJ T Cheng
May 31, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lucia MontenegroGiuseppe Romeo
Aug 28, 2010·Journal of Animal Physiology and Animal Nutrition·E VossenS De Smet
Jan 25, 2003·The Journal of Pharmacy and Pharmacology·Yvonne WangMing-Kuan Hu
May 23, 2001·Journal of Agricultural and Food Chemistry·N PellegriniF Brighenti

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