The in vitro biotransformation of 2-aminofluorene in the visceral mass of the Pacific oyster, Crassostrea gigas

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
D Schlenk, D R Buhler

Abstract

1. The in vitro biotransformation of 2-aminofluorene (2-AF) was examined in visceral mass microsomes from the Pacific oyster Crassostrea gigas. 2. The major metabolite was N-formyl-2-aminofluorene with smaller quantities of N-hydroxy-2-aminofluorene and nitroso-2-aminofluorene or 2-nitrofluorene. 3. The mechanism of N-oxidation was explored using various inhibitors, stimulators, cofactors, and pH modifications within incubations. 4. N-Oxidation may occur via a one electron mechanism which involves a transition metal and/or lipid peroxidation. 5. Flavin-containing monooxygenase and possibly prostaglandin synthase also seem to play a role in N-oxidation.

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Citations

Feb 11, 1999·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·D Schlenk
Oct 31, 2015·Annual Review of Animal Biosciences·Guofan ZhangLinlin Zhang

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