The in vitro effect of a calf thymus extract on the peripheral blood lymphocytes of patients with warts

The British Journal of Dermatology
M G BernengoG Zina

Abstract

T and B lymphocyte populations were evaluated in forty-one patients with multiple recurring warts. Active rosettes (T-Ea) and total T lymphocytes (T-Et) were significantly decreased. The in vitro effect of a calf thymus extract (TP-I) on peripheral blood lymphocytes was evaluated in thirty-three patients. A statistically significant increase in E-rosette forming cells was observed in twenty-three patients (69%). Serum blocking factors were not found in the patients with a positive response to TP-I, which suggests the possibility of a thymic hormone deficiency. In the case of non-responders to TP-I, on the other hand, an anti-lymphocyte antibody capable of directly blocking the hormone receptors on the undifferentiated lymphocytes may be postulated.

References

May 1, 1976·The Medical Clinics of North America·A L GoldsteinJ T Ulrich
Jan 9, 1975·The New England Journal of Medicine·D W WaraA J Ammann
Feb 27, 1975·The New England Journal of Medicine·H H FudenbergD Robbins
Nov 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·J F BachA White
May 1, 1974·The British Journal of Dermatology·W L Morrison
Nov 1, 1970·The Journal of Experimental Medicine·B PernisL Amante

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Citations

Oct 1, 1983·Pediatric Dermatology·M E BenderF Pass
Mar 1, 1983·Journal of the American Academy of Dermatology·K KangJ M Hanifin
Oct 1, 1982·American Journal of Reproductive Immunology : AJRI·A VelardiM F Martelli

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