PMID: 591094Jan 1, 1977

The in vitro effects of calcium and potassium in resensitization of tracheal smooth muscles of the allergized guinea pig

International Archives of Allergy and Applied Immunology
F Alonso-Deflorida, A Del Castillo


Tracheal smooth muscle obtained from allergized guinea pigs gives rise in vitro to two-phase cycles of responsiveness to antigen administration desensitization produced immediately after a conditioning antigen dose, followed by resensitization within 4 h. As in the case of resensitization to a drug, resensitization to an antigen is a Ca++- and K+-dependent phenomenon. A comprehensive receptor model of the chemical excitatory action of antigen in cells is consistent with a Ca++-dependent resensitization phenomenon in the allergized systems. On the other hand, the results bear weight against both a 'pharmacological mediator-depletion theory' and an 'antibody saturation-desaturation theory', which have been invoked to explain desensitization and resensitization to antigen in allergized systems.

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