Abstract
Statins enhance the synthesis of long-chain polyunsaturated fatty acids (LC-PUFAs) from their precursors both in vitro and in vivo. In particular, an increased conversion of linoleic acid (LA) and of alpha-linolenic acid to their derivatives is observed in cultured cells. On the contrary, cigarette smoke (CS) negatively and dose-dependently affects the LC-PUFA production. To evaluate the effects of CS alone or with simvastatin, on [1-(14)C] LA metabolism in THP-1 cells. CS inhibits LA conversion; after co-incubation, simvastatin nullifies the effects of CS, maintaining LA conversion comparable to controls. However, at the highest CS concentration, simvastatin is unable to counteract the effects of CS. Changes of LA conversion reflect the modulation of desaturase activities by simvastatin and CS. CS decreases PUFA conversion and its effects are modulated by the opposite effect of statins. It can be speculated that statin treatments in smoking patients may provide some beneficial effects on PUFA metabolism in addition to lowering cholesterol levels.
References
Dec 1, 1985·Environmental Health Perspectives·D F Church, W A Pryor
Apr 1, 1995·Toxicology Letters·R K SindhuY Kikkawa
Feb 1, 1994·Archives of Biochemistry and Biophysics·G C NessZ Zhao
Apr 1, 1993·Journal of the Royal Society of Health·B Halliwell
Jul 1, 1996·Chest·B K DoM P Habib
Aug 15, 1996·American Journal of Epidemiology·J A SimonW S Browner
Mar 14, 1998·Toxicology and Applied Pharmacology·P H VillardB Lacarelle
Dec 16, 1998·Lancet·C Campbell
Dec 16, 1998·Lancet·C AgostoniC Galli
Jul 27, 1999·Lipids·R PawloskyN Salem
Sep 27, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·P RiséC Galli
Sep 28, 2002·Journal of Cardiovascular Pharmacology·Sandrine DelboscJean-Paul Cristol
Jan 23, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Johnathan A NapierOlga Sayanova
Apr 23, 2003·European Journal of Pharmacology·Patrizia RiséClaudio Galli
Jun 10, 2003·Clinical Science·Justin C Mason
Nov 19, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Ravinder D Reddy, Jeffrey K Yao
Dec 14, 2004·Lipids·Franca MarangoniClaudio Galli
Mar 15, 2005·Biochemical Pharmacology·Patrizia RiséClaudio Galli
Dec 13, 2005·Circulation Research·Yoshiyuki Rikitake, James K Liao
Jan 20, 2007·Journal of Lipid Research·Robert J PawloskyNorman Salem
Jun 7, 2007·Lipids·Silvia GhezziClaudio Galli
Jul 28, 2007·European Journal of Pharmacology·Patrizia RiséClaudio Galli
Dec 1, 2007·Journal of Cardiovascular Pharmacology·Gehan HeebaTadeusz Malinski
Dec 25, 2007·Atherosclerosis·Nicole SchuppHelga Stopper