The in vitro effects of phosphodiesterase inhibitors on the human internal mammary artery

Anesthesia and Analgesia
M Salmenperä, J H Levy

Abstract

The internal mammary artery (IMA) is the preferred conduit for myocardial revascularization, but it changes diameter in response to injury or thromboxane release to decrease myocardial blood supply. Papaverine, a phosphodiesterase (PDE) inhibitor, is injected in the IMA bed during surgery to prevent spasm. We evaluated the ability of papaverine and cyclic adenosine monophosphate PDE Type III (cAMP-PDE) inhibitors (amrinone, enoximone, and milrinone) in vitro to reverse the constriction of human IMA rings, induced by a thromboxane A2 analog, U46619, and evaluated amrinone's ability to modify the constricting effect of norepinephrine (NE). All cAMP-PDE inhibitors produced complete relaxation of U46619-induced contractions. The contractions necessary to produce 50% relaxation (EC50) were within therapeutic ranges. The vasodilatory potency of amrinone was greater after NE than after U46619 (EC50, 1.9 +/- 0.5 vs 4.3 +/- 2.2 x 10(-5)M; mean +/- SD; P < 0.05). Response to constriction after a submaximal dose of NE was attenuated to 38% (P < 0.001) from that observed in the control rings by a pretreatment with amrinone. These results suggest that cAMP-PDE inhibitors have the potential utility to reverse IMA spasm, and represent a poten...Continue Reading

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Citations

Sep 20, 2002·The Annals of Thoracic Surgery·Gianluca PolvaniPaolo Biglioli
Jan 13, 2001·British Journal of Pharmacology·T J BatchelorD J Beech
Aug 5, 2000·Anaesthesia·K P LewisR H Bode
Oct 11, 2013·Annals of Cardiac Anaesthesia·Divya GopalAshwini Thimmarayappa
Apr 18, 2006·Journal of Cardiothoracic and Vascular Anesthesia·Janne P KarhunenUlla-Stina Salminen
Feb 21, 2002·Journal of Cardiothoracic and Vascular Anesthesia·Cheri A SulekEmilio B Lobato
May 15, 2009·Journal of Cardiac Surgery·Yavuz Beşoğul
Sep 15, 2004·Journal of Cardiothoracic and Vascular Anesthesia·Francesco OnoratiMaurizio Cotrufo
Feb 9, 2002·The Annals of Thoracic Surgery·Jerrold H LevyG Michael Deeb
Nov 5, 1999·Journal of Cardiovascular Pharmacology·J L CracowskiP Devillier
Jan 24, 2006·Journal of Cardiac Surgery·Susumu Manabe, Makoto Sunamori
Jan 18, 2007·Fundamental & Clinical Pharmacology·M O SerbestO Oto
Sep 22, 2009·Canadian Journal of Physiology and Pharmacology·Olcay Murat DisliAhmet Parlak

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