The in vitro elution of gentamicin sulfate from a commercially available gentamicin-loaded acrylic bone cement, VersaBond AB

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
G Lewis, Si Janna

Abstract

The present study was designed to yield results that would be used to contribute to the ongoing debate about the mechanism of the in vitro elution of an antibiotic from an antibiotic-loaded acrylic bone cement. To this end, the elution rates (R) of gentamicin sulfate (expressed as a weight percentage of the initial mass of the antibiotic in the specimen, normalized with respect to the duration of the test) from statically loaded (STATIC) and dynamically loaded (+/-10 MPa; 2 Hz; until fracture; DYNAMIC) specimens fabricated from a commercially available acrylic bone cement (VersaBond AB), in phosphate-buffered saline solution at 37 degrees C, were obtained with the use of a spectrophotometric method. There was evidence of microcracking in the fracture surfaces of DYNAMIC specimens, but no such evidence in the case of STATIC specimens. The surface area of the DYNAMIC specimens, during the tensile phase of the cyclical loading, was estimated to be about 3% larger than for the STATIC specimens (1742 mm(2) versus 1696 mm(2)). The bulk porosities P of the specimens in both sets were also determined and found to not be statistically different, with P for the STATIC and DYNAMIC specimens being 8.55 +/- 0.10 and 8.88 +/- 0.18%, respecti...Continue Reading

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Citations

Aug 10, 2011·Expert Opinion on Drug Safety·Ippokratis PountosPeter V Giannoudis
Jun 21, 2016·Expert Opinion on Drug Delivery·Vuk Uskoković, Shreya Ghosh
Sep 8, 2010·Journal of Biomaterials Applications·Christine S LewisRonald R Cobb
Jan 21, 2014·Journal of Dairy Science·S H I LeeC A F Oliveira
Oct 20, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Shou-Cang ShenReginald Beng Hee Tan
Oct 1, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Gladius Lewis
Dec 19, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Xun-Zi CaiJia Xu
Oct 22, 2008·Critical Reviews in Biotechnology·C Ganesh KumarAnnapurna Jetty
Sep 8, 2010·Journal of Biomaterials Applications·Elke VorndranUwe Gbureck
Nov 23, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Serkan InceogluVictoria K Maskiewicz

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