The in vitro, in vivo antifungal activity and the action mode of Jelleine-I against Candida species

Amino Acids
Fengjing JiaRui Wang

Abstract

Recently, the mortality of life-threatening fungal infections increased dramatically. However, there are few antifungals existed. Antimicrobial peptides (AMPs) as promising antifungal candidates have attracted much attention. Here, we present a small antimicrobial peptide Jelleine-I that had potent in vitro and in vivo antifungal activity. Negligible hemolytic activity and in vivo toxicity were observed. Selectivity index (SI) of Jelleine-I is at least 4.6 times higher than amphotericin B. Jelleine-I could increase the production of cellular ROS and bind with genome DNA. This may contribute to its antifungal activity. Furthermore, drug resistance is not induced when the fungal cells were repeatedly treated by Jelleine-I. In conclusion, our results suggest that Jelleine-I may have the potential to be developed as a novel antifungal agent.

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Citations

Jul 4, 2020·Biofouling·Amanda Carolina Borges da SilvaMaria Lígia Rodrigues Macedo
Jun 6, 2020·Applied Microbiology and Biotechnology·Hamed Memariani, Mojtaba Memariani
Nov 11, 2018·Toxins·Qinghua WuKamil Kuča
Sep 6, 2018·Journal of Economic Entomology·Praetinee PattamayutanonPanuwan Chantawannakul
Feb 3, 2021·Proceedings. Biological Sciences·Steve KettMassimiliano Marvasi
Jul 6, 2021·Frontiers in Chemistry·Tanumoy SarkarSunanda Chatterjee
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Magdalena RatajczakJan Matysiak
Nov 13, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Kang DingXiangli Dang

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Methods Mentioned

BETA
Assay
confocal microscopy
flow cytometry

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