PMID: 108818Apr 1, 1979

The in vitro metabolism of progesterone, 4-androstene-3,17-dione, testosterone and 17 beta-hydroxy-5 alpha-androstan-3-one by fetal rhesus monkey testes

J C Coffey, R E Johnsonbaugh


Homogenates prepared from fetal rhesus monkey testes were incubated with progesterone, 4-androstene-3,17-dione, testosterone and 17 beta-hydroxy-5 alpha-androstan-3-one. The major progesterone metabolite was 17-hydroxy-4-pregnene-3,20-dione. Testosterone also accumulated in the progesterone incubations. 4-Androstene-3,17-dione was converted chiefly to testosterone. Testosterone was not actively metabolized by the fetal monkey testis. 17 beta-Hydroxy-5 alpha-androstan-3-one was actively converted primarily to 5 alpha-androstane-3 beta,17 beta-diol.


Mar 1, 1967·Endocrinology·D C SharmaR I Dorfman
Jul 1, 1967·Steroids·J C Hoschoian, A C Brownie


Aug 1, 1980·Journal of Steroid Biochemistry·J P Preslock
Jan 1, 1985·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·H InanoB Tamaoki

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