PMID: 6984087Mar 1, 1981Paper

The in vitro resistance of canine staphylococci to trimethoprim and sulphamethoxazole alone and in combination

Journal of Veterinary Pharmacology and Therapeutics
M HintonJ Crisfield

Abstract

The in vitro resistance of 40 strains of Staphylococcus aureus isolated from dogs to trimethoprim, sulphamethoxazole and co-trimoxazole (SXT) was assessed using the disc diffusion technique on Diagnostic Sensitivity Test Agar (DSTA), DSTA with 5% lysed horse blood (DSTA + B), IsoSensitest Agar (ISTA) and Wellcotest Sensitivity Test Agar (WSTA). When sensitivity was based on a zone width of greater than or equal to 4 mm all 40 strains were sensitive to SXT on DSTA + B and ISTA, 39 were sensitive on WSTA while only 31 (77.5%) were sensitive on DSTA. A comparison of the results obtained for each strain for trimethoprim and sulphamethoxazole with those obtained with the Oxford strain of S. aureus and using a scheme for interpretation recommended by Garrod & O'Grady (1971) indicated that the proportion of strains classed as sensitive for therapeutic purposes was 5%, 55%, 47.5% and 15% respectively on DSTA, DSTA + B, ISTA and WSTA.

References

Apr 1, 1978·The Journal of Small Animal Practice·M HintonR Hedges
Jan 1, 1967·Antimicrobial Agents and Chemotherapy·S Kinrick, P R Laibson
Jul 1, 1973·In Vitro·F C ChuJ C Petricciani
Jan 1, 1969·Postgraduate Medical Journal·J A KuzemkoF P Hudson
Dec 1, 1971·Journal of Clinical Pathology·L P Garrod, P M Waterworth

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