The in vitro stability of air-filled polybutylcyanoacrylate microparticles

Biomaterials
Carsten OlbrichMichael Schirner

Abstract

Different methods of manufacturing permitted the production of air-filled PBCA microparticles (af-pbca-mp) with different physical properties such as size and wall thickness. These differences led to distinctions with respect to mechanical stability and, at the same time, to different levels of biochemical stability when incubated in biofluids. Microparticles, designed as they are to be mechanically more stable (composed of larger nanoparticles resulting in thicker shell wall, no surface hydrolysis), persist longer under in vitro conditions in biofluids such as serum, plasma and whole blood than do the more fragile ones. It was possible when using the measurement of ultrasound attenuation to characterize af-pbca-mp degradation with respect to the disappearance of the ultrasound properties of the particles and therefore to find out how long different formulations can be expected to be active as contrast agents under simulated in vivo conditions. The present examination showed that using either serum, plasma or whole blood leads to results with the same tendencies in terms of the stability and durability of af-pbca-mp in the media, mimicking in vivo conditions. It was thus possible to validate successfully the use of either serum...Continue Reading

Citations

Jun 12, 2009·Medical & Biological Engineering & Computing·Alexander L Klibanov
Sep 4, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Stefanie Nippe, Sascha General
Sep 20, 2011·Ultrasound in Medicine & Biology·Stanley FokongJessica Gätjens
Oct 7, 2015·Frontiers in Pharmacology·Vera PaefgenFabian Kiessling

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