The in vivo apoptotic effect of interferon alfa-2b on rat preneoplastic liver involves Bax protein

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
María de Luján AlvarezMaría Cristina Carrillo

Abstract

To determine whether interferon alfa (IFN-alpha) prevents in vivo oncogenesis in very-early-stage cancer cells, we evaluated the action of IFN-alpha2b over preneoplastic foci in rats. Animals were divided into 6 groups: subjected to a 2-phase model (diethylnitrosamine [DEN] plus 2-acetylaminofluorene [2-AAF]) of preneoplasia development (group 1), treated with IFN-alpha2b during the 2 phases (group 2), only during initiation with DEN (group 3), only during administration of 2-AAF (group 4), subjected only to an initiation stage (group 5), and treated with IFN-alpha2b during this period (group 6). The numbers of placental form of rat glutathione S-transferase (rGST-P)-positive foci per liver and the foci as percentage of liver were significantly reduced in groups 2, 3, and 6 but not in group 4. Rats treated with IFN-alpha2b showed a higher apoptotic index (AI) in altered hepatic foci (AHF). Levels of p53 and Bax protein in liver lysates were significantly increased in those animals. Similarly, levels of antiapoptotic proteins Bcl-2 and Bcl-x(L) in mitochondrial fraction were decreased. Finally, increased levels of Bax protein were localized in the mitochondria of rats that received IFN-alpha2b, at least during the DEN phase (gro...Continue Reading

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Citations

Mar 7, 2007·Archives of Toxicology·Juan Pablo ParodyMaría Cristina Carrillo
Aug 6, 2005·Journal of Gastroenterology·Kazuya MatsumotoYoshikazu Murawaki
Dec 27, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Katja PokrovskajaDan Grandér
Nov 13, 2008·Growth Factors·María De Luján AlvarezMaría Cristina Carrillo
Sep 16, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·María de Luján AlvarezMaría Cristina Carrillo
Sep 21, 2010·The Journal of Surgical Research·Yusuke ArakawaTetsuya Ikemoto
Jun 22, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·I BorbathY Horsmans
Oct 15, 2013·Molecular Nutrition & Food Research·María Laura CasellaMaría de Luján Alvarez
Dec 3, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Juan P ParodyMaria C Carrillo
Mar 21, 2007·Biochemical Pharmacology·Ariel D QuirogaMaría Cristina Carrillo
Nov 3, 2004·Journal of Hepatology·Toru HisakaMasamichi Kojiro
Jul 23, 2016·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Gerardo Bruno PisaniAlejandra Beatriz Quintana
Aug 16, 2016·Biochimica Et Biophysica Acta·Ariel D QuirogaMaría C Carrillo
Mar 4, 2017·European Journal of Nutrition·Alejo M CapiglioniMaría de Luján Alvarez
Sep 28, 2018·Food & Function·Nisha Susan ThomasAthavan Alias Anand Selvam
Dec 5, 2019·Scientific Reports·Florencia LorenzettiMaría de Luján Alvarez
Feb 16, 2019·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Marina Cecilia VeraAlejandra Beatriz Quintana
Jun 21, 2021·The Journal of Nutritional Biochemistry·Marina C VeraAriel D Quiroga

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