PMID: 6165780Jun 1, 1981Paper

The in vivo effects of lymphokines on mitotic activity and keratinization in guinea pig epidermis

The Journal of Investigative Dermatology
A K KorszunN W Johnson

Abstract

Lymphokines may alter epidermal growth and differentiation contributing to changes such as acanthosis and hyperkeratosis. The main in vivo effects of lymphokines on epidermal mitotic activity were therefore investigated. Guinea pigs were injected intradermally with antigen-stimulated lymphocyte culture supernatants and a partially purified lymphokine preparation in phosphate buffered saline (PBS) 18, 24, 36 and 48 hr prior to biopsy. Control sites were injected with unstimulated supernatants and PBS respectively and the mitotic activity determined by use of a stathmokinetic agent. Both lymphokine injected areas and controls showed significantly increased mitotic indices compared to untreated skin which was apparent only at 24 hr. However mitotic activity in lymphokine lesions was significantly higher than in control lesions. There was no difference in the effect on mitotic activity between PBS and unstimulated culture supernatants. Lymphokine lesions at 24 hr also exhibited marked epidermal edema and acanthosis compared to minimal changes in controls. A variable patchy parakeratosis developed between 18 and 24 hr in areas injected with partially purified lymphokine but not in control sites or after injection with unpurified sup...Continue Reading

Citations

Apr 1, 1988·Journal of Oral Pathology·Z GaoE B Lane
Feb 1, 1988·The British Journal of Dermatology·J D Bos
Apr 1, 1993·Journal of Cutaneous Pathology·L Kanerva, K M Niemi
Apr 1, 1987·The British Journal of Dermatology·B S BakerL Fry
Aug 1, 1990·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M F ReedJ V Soames
Jan 1, 1988·Archives of Dermatological Research·T TanakaM Takigawa
May 1, 1984·The British Journal of Dermatology·B S BakerH Valdimarsson
Jan 1, 1987·The British Journal of Dermatology·T TeruiH Tagami
Jul 1, 1983·The Journal of Investigative Dermatology·F GreenE Balish
Aug 1, 1982·The Journal of Investigative Dermatology·F GreenE Balish

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