The in-vivo occurrence of Z DNA

Journal of Biomolecular Structure & Dynamics
D B Haniford, D E Pulleyblank

Abstract

The energetics of the B-Z transition of two different types of cloned alternating purine/pyrimidine DNA sequences have been analysed by a two dimensional electrophoretic technique. Since the transition between right handed and left handed forms of these polymers is detected by alterations of electrophoretic mobilities of topoisomers of the plasmid DNA molecules, the method is not dependent on Z-DNA binding ligands. The measurements reflect intrinsic properties of the DNA unperturbed by the free energy of binding such a ligand. Direct evidence from the analysis of topoisomer distributions is presented which shows that d(GC)n.d(GC)n sequence elements within an E. coli plasmid will adopt a Z conformation in-vivo under conditions of blocked protein synthesis. Evidence for the in-vivo occurrence of Z-DNA was not detected in plasmid DNA isolated from bacterial cells growing in the absence of protein synthesis inhibitors. A model is proposed for a function for the B-Z transition in ensuring the correct pairing of homologous chromosomes during meiosis.

References

May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J E GermondP Chambon
Nov 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·D E Depew, J C Wang
Nov 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·M GellertH A Nash
Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A SuginoN R Cozzarelli
Jan 1, 1978·Annual Review of Biophysics and Bioengineering·W R Bauer
Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J C Wang
Apr 5, 1978·Journal of Molecular Biology·K Drlica, M Snyder
Feb 9, 1978·Nature·W Gilbert
Sep 15, 1972·Nature·I GresserD Brouty-Boyé
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·D E Pettijohn, O Pfenninger
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R M SantellaA Rich
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M Behe, G Felsenfeld
Jul 23, 1981·Nature·D M Lilley
Jun 24, 1982·Nature·A J Beattie, D C Culver
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A NordheimA Rich
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·C K SingletonR D Wells
Jan 1, 1983·Cold Spring Harbor Symposia on Quantitative Biology·T M JovinM Robert-Nicoud
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A Nordheim, A Rich
Nov 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·H HamadaT Kakunaga
Sep 19, 1980·Science·C P LiuF R Blattner
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·L J PeckJ C Wang
Feb 21, 1980·Nature·S ArnottR L Ratliff
Aug 7, 1980·Nature·H DrewR E Dickerson

❮ Previous
Next ❯

Citations

Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·F AzorinA Rich
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M J EllisonA Rich
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R J KelleherA Rich
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·W ZachariasR D Wells
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J A McClellanD M Lilley
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A G HerbertA Rich
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·A HerbertA Rich
Dec 1, 1983·Journal of Biomolecular Structure & Dynamics·B RevetA Niveleau
Aug 1, 1995·Journal of Biomolecular Structure & Dynamics·P PecinkaE Palecek
Aug 1, 1990·The Journal of Cell Biology·M O Soyer-GobillardE Delain
Jun 25, 1985·Nucleic Acids Research·D B Haniford, D E Pulleyblank
Dec 25, 1991·Nucleic Acids Research·H JiangS Amirhaeri
Aug 15, 1998·Nucleic Acids Research·K J DejJ D Boeke
Aug 24, 2013·Nucleic Acids Research·Dina Zhabinskaya, Craig J Benham
Feb 2, 2011·PLoS Computational Biology·Dina Zhabinskaya, Craig J Benham
May 10, 2012·PLoS Computational Biology·Dina Zhabinskaya, Craig J Benham
Jul 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·L PostowN R Cozzarelli
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·A HerbertA Rich
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·Y G KimA Rich
Jan 1, 1991·Critical Reviews in Biochemistry and Molecular Biology·E Palecek
Oct 8, 1999·Journal of Molecular Biology·A S KrasilnikovS M Mirkin
Mar 20, 1987·Journal of Molecular Biology·J B Bliska, N R Cozzarelli
Sep 1, 1995·Electrophoresis·S K BrahmachariS Pataskar
Jan 1, 1991·Journal of Clinical Laboratory Analysis·J A ThompsonW Zimmermann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
L J Peck, J C Wang
Journal of Biomolecular Structure & Dynamics
A V Vologodskii, M D Frank-Kamenetskii
© 2021 Meta ULC. All rights reserved