The in vivo pH of the extravascular space of the lung

The Journal of Clinical Investigation
R M Effros, F P Chinard

Abstract

The partition of 5,5-dimethyloxazolidine-2,4-dione (DMO) and of 11 amines between the vascular and extravascular spaces of the lung has been determined by the multiple indicator dilution technique. Four amines (nicotine, pentylamine, quinine, and benzylamine) were found to have pH-sensitive tissue to blood concentration ratios. Of these, tritiated nicotine appears to be the nost satisfactory indicator of tissue pH and values for the pH of the pulmonary extravascular space (pH(e)) have been calculated from the nicotine data. At an arterial pH (pH(art)) between 7.38 and 7.43 pH(e) averaged 6.69 +/-0.07. Changes in pH(e) usually paralleled but were consistently less than concomitant changes in pH(art). Alterations in P(CO2) at constant pH(art) regularly produced relatively small, parallel changes in extravascular hydrogen ion concentrations. Local alterations in tissue pH due to P(CO2) changes are apparently buffered quite rapidly and the pH(e) of the lung seems more closely linked to pH(art) than the cellular pH of other tissues.DMO, guanidine, methylamine, morphine, and atropine were confined to the vascular volume during the first circulation and could not be used to measure tissue pH. Histamine appeared to be bound to a pH-ins...Continue Reading

Citations

Dec 26, 2001·The American Journal of Medicine·R M EffrosW Lin
Sep 1, 1979·Acta Physiologica Scandinavica·G ClausenK Aukland
Sep 1, 1970·Circulation Research·T Yipintsoi, J B Bassingthwaighte
Sep 1, 1974·Circulation Research·J B Bassingthwaighte
Feb 1, 1972·The Journal of Clinical Investigation·S Adler
May 1, 1975·The Journal of Clinical Investigation·R M EffrosT J Regan
May 1, 1983·The Journal of Clinical Investigation·R M Effros, S Nioka
Oct 4, 1980·British Medical Journal
Mar 2, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Brent CaldwellJulian Crane
Dec 4, 2014·International Journal of Medical Microbiology : IJMM·Noha M ElhosseinyAhmed S Attia
Oct 8, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nicholas DrachmanRahim Rizi
Mar 14, 2016·Current Opinion in Chemical Biology·Otonye Braide-MoncoeurJoanna R Long
Aug 1, 1971·Circulation Research·W H Ziegler, C A Goresky
Jan 1, 1982·Medical and Pediatric Oncology·S Harguindey
Mar 25, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Richard M EffrosRichard Casaburi
Nov 1, 2013·International Journal of Oncology·Anne-Kristin VahleChristian Stock
Nov 2, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ricardo MurphyThomas E DeCoursey
Mar 29, 2003·Physiological Reviews·Thomas E Decoursey
Jul 10, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·R M EffrosB Foss
Dec 25, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Kalyan C Vinnakota, James B Bassingthwaighte
Jan 1, 1970·Acta Pharmacologica Et Toxicologica·A Ryrfeldt
Mar 7, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Dilip JosephRichard L Lubman
Jan 12, 2013·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Tennyson L DoaneClemens Burda
Dec 12, 2020·Frontiers in Public Health·Carlos M DuarteMariusz Jaremko
Nov 2, 2019·Molecular Metabolism·Peter KreuzalerMariia Yuneva
Mar 1, 1980·The American Journal of Physiology·R A GarrickF P Chinard
Sep 21, 2021·Antimicrobial Agents and Chemotherapy·Frédéric PeyrussonFrançoise Van Bambeke

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