The in vivo trypanocidal effect of the diterpene 5-epi-icetexone obtained from Salvia gilliesii

Parasitology International
Esteban LozanoMiguel A Sosa

Abstract

The search for new compounds with trypanocidal activity is crucial for the treatment of Chagas' disease. Previous in vitro studies have shown that the diterpene 5-epi-icetexone (ICTX) is active against Trypanosoma cruzi. The aim of this work was to evaluate the effect of ICTX on the parasites in infected mice, in an experimental model that mimics the acute phase of the disease. Swiss albino mice were infected with T. cruzi and treated daily with 10mg/kg/day ICTX (i.p.). Infected mice and mice injected with either saline or the vehicle DMSO were used as controls. Animals' survival and parasitemia were monitored once a week and histological studies were made at necropsy by the 5th week after infection. It was observed that the administration of ICTX increased the survival of mice infected, and induced a significant decrease in the parasitemia, as compared to controls. A similar protective effect was observed when animals were treated orally with benznidazole (BZN, used as a control of antiparasitic effect). By the 5th week post-infection, the presence of amastigote nests was observed within the fibers of the cardiac and skeletal muscle in controls, but not in animals treated with either ICTX or BZN. In addition, inflammatory infi...Continue Reading

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Citations

Nov 30, 2016·Phytotherapy Research : PTR·Marcus Vinícius Oliveira Barros de AlencarMd Torequl Islam
Jan 18, 2018·International Journal of Molecular Sciences·Núria Llurba-Montesino, Thomas J Schmidt
Oct 25, 2020·Natural Product Research·Ana Carolina F S RochaVladimir C G Heleno
Apr 10, 2021·Journal of Experimental Pharmacology·Ana Lia MazzetiVanessa Carla Furtado Mosqueira
Feb 18, 2021·Current Pharmaceutical Design·Aline A Zuma, Wanderley de Souza

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