The inability of chronic mianserin to block central alpha 2-adrenoceptors

European Journal of Pharmacology
M F Sugrue

Abstract

An investigation was undertaken of the effect of long-term mianserin administration on the clonidine-induced decrease in rat brain MHPG-SO4 content. The dose of clonidine (0.1 mg/kg) chosen was one considered to selectively activate central alpha 2-adrenoceptors. Mianserin (10 mg/kg) given once daily for 9 and 15 days failed to alter the response to clonidine. This contrasts with the observations that acute and 5 day mianserin treatment blocks the clonidine-induced reduction in rat brain MHPG-SO4 levels. The possibility of mianersin-induced changes in the sensitivity of alpha 2-adrenoceptors is discussed. Chronic mianserin administration was associated with elevated levels of MHPG-SO4. This may have resulted from blockade of alpha 1-adrenoceptors.

References

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Citations

Mar 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·Y PommierH Schmitt
Aug 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·M F Sugrue
Jan 1, 1984·Journal of Psychiatric Research·A RoseM J Rand
Sep 1, 1990·Pharmacology, Biochemistry, and Behavior·R L CommissarisD J Fontana
Jul 1, 1992·Progress in Neuro-psychopharmacology & Biological Psychiatry·Y MizukiM Yamada
Jan 1, 1982·Progress in Neuro-psychopharmacology & Biological Psychiatry·G Kato, T Ban
Sep 5, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Bogusława Pietrzak, Elzbieta Kubik-Bogucka
May 20, 1999·Journal of Affective Disorders·N HaddjeriC de Montigny
Jan 1, 1981·Pharmacology & Therapeutics·M F Sugrue
Nov 1, 1984·Pharmacology, Biochemistry, and Behavior·E PrzegalińskiK Bigajska
Jun 15, 1983·Biochemical Pharmacology·M F Sugrue
Aug 1, 1984·The Journal of Pharmacy and Pharmacology·M F Sugrue
Jan 1, 1985·Journal of Neuroscience Research·F Cerrito, P Preziosi

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