PMID: 8595874Jan 15, 1996Paper

The inactivation of hexokinase activity does not prevent glucose repression in Candida utilis

FEMS Microbiology Letters
A E EspinelJ M Peinado

Abstract

High hexokinase activity was not related to glucose repression in Candida utilis IGC 3092. The addition of Cibacron Blue 3G-A to growing cells in batch culture led to a permanent in vivo hexokinase inactivation, decreased growth rate and inhibited alcohol dehydrogenase. Hexokinase inactivation up to 90% did not alleviate glucose repression of alpha-glucosidase, as has been described for Saccharomyces cerevisiae and other yeasts. Moreover, when cells were physiologically derepressed by growing them in a chemostat at low glucose concentrations, the highest hexokinase activity was shown by the derepressed cells, and decreased as repression increased. Thus, in our strain of C. utilis, hexokinase activity was inversely proportional to glucose repression.

References

Jun 1, 1992·European Journal of Biochemistry·J M Gancedo
Sep 1, 1989·Journal of General Microbiology·E M McGoldrick, A E Wheals
Dec 1, 1986·Journal of General Microbiology·R FernándezF Moreno
Dec 1, 1994·Yeast·J M Thevelein
Jul 1, 1994·Microbiology·R A WeusthuisJ T Pronk
Jan 1, 1994·Folia Microbiologica·A E Espinel, J M Peinado

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Citations

Sep 9, 2000·FEMS Microbiology Reviews·C L FloresC Gancedo
May 14, 1999·Trends in Plant Science·N G HalfordD G Hardie
Jun 10, 1998·Microbiology and Molecular Biology Reviews : MMBR·J M Gancedo

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