The (in)adequacy of translational research in dentistry

European Journal of Oral Sciences
Clovis Mariano Faggion

Abstract

Translational research, as the name suggests, "translates" research findings into clinical practice to improve the health of human beings. The translational process builds on information from experiments conducted at a basic level (i.e., in vitro and/or animal studies) and progresses over experimental human studies for efficacy, efficiency, and safety to implementation. Therefore, all steps in the process should be based on studies conducted with the highest methodological quality possible in order to provide accurate and useful information. Furthermore, the systematic dissemination of new procedures/techniques should be done only when they have been proven to be effective and safe. This focus article describes examples of new techniques/procedures in dentistry that have not resulted from an adequate translational research process since the initial evidence was published. These procedures are generally characterised by lack of good evidence, particularly on their potential harms, and lack of adequate chronological order, regarding the translational research process (i.e., human research being conducted before animal research). Even so, they seem to be widely disseminated, and their promotion involves a wide range of sources, in...Continue Reading

References

Jan 1, 1995·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·P M Tostevin, H Ellis
Jun 19, 2004·BMJ : British Medical Journal·David AtkinsUNKNOWN GRADE Working Group
Jan 25, 2007·JAMA : the Journal of the American Medical Association·John M WestfallLyle Fagnan
Jan 1, 2006·Aesthetic Surgery Journal·Sydney R Coleman, Rajiv Grover
May 27, 2010·JAMA : the Journal of the American Medical Association·Isabelle BoutronDouglas G Altman
Aug 18, 2010·Journal of Clinical Periodontology·Markus B HürzelerStefan Fickl
Sep 22, 2011·Anesthesiology·Andrew Davidson
Jan 24, 2013·The International Journal of Periodontics & Restorative Dentistry·Joseph Y K Kan, Kitichai Rungcharassaeng
Apr 11, 2013·Nature Reviews. Neuroscience·Katherine S ButtonMarcus R Munafò
Aug 10, 2013·Journal of Translational Medicine·Andre BarkhordarianFrancesco Chiappelli
Oct 22, 2013·JAMA : the Journal of the American Medical Association·UNKNOWN World Medical Association
Jan 15, 2014·Lancet·Malcolm R MacleodPaul Glasziou
Sep 30, 2014·The International Journal of Oral & Maxillofacial Implants·Konstantinos D SiormpasGeorgios A Kotsakis
Feb 17, 2015·European Journal of Oral Sciences·Clovis M Faggion
Apr 17, 2015·Nature·Daniel Cressey
Sep 15, 2015·Cambridge Quarterly of Healthcare Ethics : CQ : the International Journal of Healthcare Ethics Committees·Aysha Akhtar
Oct 29, 2015·The International Journal of Periodontics & Restorative Dentistry·Miltiadis E MitsiasGeorgios A Kotsakis
Jan 17, 2016·Journal of Clinical Epidemiology·Ignacio NeumannGordon H Guyatt
Apr 23, 2016·The International Journal of Periodontics & Restorative Dentistry·Howard GluckmanMaurice Salama
Aug 28, 2016·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·José Luis Calvo-GuiradoSergio Alexandre Gehrke
Jan 14, 2017·The Journal of Oral Implantology·Hong HuangGang Fu
Feb 13, 2017·Journal of Esthetic and Restorative Dentistry : Official Publication of the American Academy of Esthetic Dentistry ... [et Al.]·Reza Saeidi PourAnja Liebermann
Mar 24, 2017·Clinical Oral Implants Research·Daniel BäumerMarkus Hürzeler
Aug 5, 2017·Laboratory Animals·Adrian J SmithTrond Brattelid
Oct 13, 2017·The International Journal of Periodontics & Restorative Dentistry·Matthias PetschRalf-Joachim Kohal
Jan 16, 2018·BioMed Research International·Miltiadis E MitsiasGiovanna Iezzi
Jan 18, 2018·The International Journal of Oral & Maxillofacial Implants·Charles SchwimerJonathan Du Toit
Mar 1, 2018·The Journal of Craniofacial Surgery·Ennio BramantiLuigi Laino
Mar 22, 2018·The Journal of Craniofacial Surgery·Chang-Hun HanFrancesco Guido Mangano
Jun 8, 2018·Breathe·Sara Manti, Amelia Licari
Jun 21, 2018·Medicina oral, patología oral y cirugía bucal·L-B MouraV-A Pereira-Filho
Jul 3, 2018·Journal of Indian Society of Periodontology·Payal Rajender Kumar, Udatta Kher
Apr 25, 2016·JACC. Basic to Translational Science·Gail A Van Norman
Sep 14, 2018·Journal of Indian Society of Periodontology·Manjunath Mundoor DayakarPrakash Pai Gurpur
Sep 24, 2018·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·José Luis Calvo-GuiradoOfer Moses
Dec 12, 2018·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Giuditta MannelliGiuseppe Spinelli
Dec 18, 2018·The Journal of Prosthetic Dentistry·Howard GluckmanJonathan Du Toit
Jan 21, 2019·Journal of Clinical Periodontology·Zhengchuan ZhangFeilong Deng
Feb 7, 2019·The Journal of Prosthetic Dentistry·Charles W SchwimerJonathan Du Toit
Mar 30, 2019·Journal of Pharmacy & Bioallied Sciences·Kashinath C ArabbiShobha K Subbaiah
Aug 8, 2019·The Journal of Oral Implantology·Joey T Chen
Aug 20, 2019·Dental Materials : Official Publication of the Academy of Dental Materials·Leticia Cristina Cidreira BoaroFlávia Gonçalves
Aug 23, 2019·Journal of Investigative and Clinical Dentistry·Akanksha MouryaRamesh Chowdhary

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Translational Medicine @ UniSa
A AnastasioG Scarpati
Experimental Biology and Medicine
Tim Clackson
Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns
Yue-sheng Huang
© 2021 Meta ULC. All rights reserved