The Incidence and Clinical Characteristics of Acute Serum Creatinine Elevation more than 1.5 mg/dL among the Patients Treated with Tenofovir/Emtricitabine-containing HAART Regimens

Infection & chemotherapy
Sun JinHyun-Ha Chang

Abstract

The combination of tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) has been the first choice nucleoside reverse transcriptase inhibitor (NRTI) according to many reliable antiretroviral treatment (ART) guidelines because of its high efficacy. However, TDF-related renal toxicity reported in Western countries is a challenging issue regarding clinical use. We conducted this study to evaluate the incidence and characteristics of an acute increase in serum creatinine (Cr) level > 1.5 mg/dL among TDF/FTC-based highly active antiretroviral treatment (HAART)-treated patients. We retrospectively reviewed the medical records of 205 HIV-infected patients treated with TDF/FTC-containing regimens between 1 February 2010 and 30 April 2014. Three groups of TDF/FTC + ritonavir-boosted protease inhibitor (PI/r), TDF/FTC + non-nucleoside reverse transcriptase inhibitor (NNRTI), and TDF/FTC + integrase strand transfer inhibitor (INSTI), and three PI/r subgroups of TDF/FTC + lopinavir (LPV)/r, TDF/FTC + atazanavir (ATV)/r, TDF/FTC + darunavir (DRV)/r were evaluated. A total 136 patients (91 in the TDF/FTC + PI/r group, 20 in the TDF/FTC + NNRTI group and 25 in the TDF/FTC + INSTI group) were included in the statistical analysis. Four ca...Continue Reading

References

Nov 16, 2001·Revista Panamericana De Salud Pública = Pan American Journal of Public Health·UNKNOWN Panel on Clinical Practices for Treatment of HIV infection
Mar 28, 2003·AIDS·Caroline CréputDominique Nochy
Dec 23, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Florence RollotPhilippe Blanche
Apr 19, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J RölingF D Goebel
Jan 4, 2008·The Journal of Infectious Diseases·Miguel GoicoecheaUNKNOWN California Collaborative Treatment Group 578 Team
Feb 3, 2009·AIDS Patient Care and STDs·Sarah M WoodRichard M Rutstein
Mar 11, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·James J KohlerWilliam Lewis
Oct 20, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Michael HorbergDaniel Klein
Jan 22, 2010·International Journal of STD & AIDS·K J QuinnC M Donnelly
Aug 3, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ryan D CooperMarcello Tonelli
Aug 17, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Andy ChoiMichael G Shlipak
Aug 26, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rebekah L PulsUNKNOWN Altair Study Group
Mar 26, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Andrew M HallJohn O Connolly
Apr 2, 2011·Scandinavian Journal of Infectious Diseases·Leonardo CalzaPierluigi Viale
Sep 16, 2011·The Journal of Infectious Diseases·Paul E SaxUNKNOWN AIDS Clinical Trials Group Study A5202 Team
Feb 9, 2012·AIDS·Rebecca ScherzerMichael G Shlipak
Jul 20, 2014·JAMA : the Journal of the American Medical Association·Huldrych F GünthardPaul A Volberding

❮ Previous
Next ❯

Citations

Jul 19, 2017·The Pediatric Infectious Disease Journal·Torsak BunupuradahUNKNOWN HIV-NAT 015 Study Team
Apr 10, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hyejeong HongJason E Farley
Apr 10, 2019·Archives of Toxicology·Hyejeong HongJason E Farley

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.