The incidence and clinical symptomatology of Clostridium difficile infections in a community setting in a cohort of Danish patients attending general practice

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
L M SøesK E P Olsen

Abstract

Clostridium difficile infection (CDI) is gradually being recognised as a cause of morbidity in the community. We investigated the incidence and clinical characteristics of CDI in a community setting and characterised the C. difficile strains by toxin gene profiling and polymerase chain reaction (PCR) ribotyping. Patients included in the study had attended general practice, primarily because of diarrhoea; CDI patients (259 patients; 121 <2 years of age) had positive cultures for toxigenic C. difficile and non-CDI patients (455 patients) were culture-negative. Outcome variables included the frequency and duration of diarrhoea, vomiting, stomach ache, fever >38 °C, weight loss and sick leave. Data were analysed by logistic regression. CDI patients <2 and ≥2 years of age with C. difficile as the only enteropathogen in the faecal sample reported slimy stools (65% vs. 62%), stomach ache (60% vs. 75%), weight loss (50% vs. 76%) and duration of diarrhoea >15 days (59% vs. 73%) as the predominant symptoms. CDI patients ≥2 years old reported duration of diarrhoea >15 days more often compared to non-CDI patients (73% vs. 27 %, p < 0.0001). The annual incidence of CDI was 518 and 23/100,000 for patients <2 and ≥2 years of age, respectively...Continue Reading

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Citations

Jan 15, 2015·Annual Review of Medicine·J J Keller, E J Kuijper
Apr 22, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·B OlesenJ O Jarløv
Jan 15, 2015·Infectious Disease Clinics of North America·Dale N Gerding, Fernanda C Lessa
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Sep 21, 2016·Emerging Infectious Diseases·Saara M KotilaOuti Lyytikäinen
Nov 19, 2019·The Pediatric Infectious Disease Journal·Lovisa MalmqvistAnna Nilsson
Mar 24, 2016·World Journal of Gastroenterology : WJG·Lynne Vernice McFarlandShan Goh
Jan 4, 2019·Journal of Global Health·Evelyn BalsellsHarish Nair

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