The Incidence and Predisposing Factors of John Cunningham Virus-Induced Progressive Multifocal Leukoencephalopathy in Southern Finland: A Population-Based Study

Open Forum Infectious Diseases
Marge KartauVeli-Jukka Anttila

Abstract

The aim of this study was to assess the prevalence, incidence rate (IR), predisposing factors, survival rate, and diagnostic delay of progressive multifocal leukoencephalopathy (PML) across medical specialties. Another objective was to survey how PML diagnosis was made in the studied cases. This is a cross-sectional retrospective observational study of PML cases across different medical specialties during 2004-2016 in the Finnish Capital Region and Southern Finland. Data were obtained from clinical records, clinical microbiology, pathology and radiology department records, and human immunodeficiency virus (HIV) quality register medical records. A total of 31 patients were diagnosed with PML. The prevalence of PML was 1.56 per 100 000 people and the IR was 0.12 per 100 000 individuals per year during 2004-2016. Hematologic malignancies (n = 19) and HIV/acquired immune deficiency syndrome (n = 5) were the most common underlying diseases, and all patients who had malignant diseases had received cancer treatment. Before PML diagnosis, 21 (67.7%) patients were treated with chemotherapy, 14 (45.2%) patients with rituximab, and 1 patient (3.2%) with natalizumab. Two patients (6.5%) had no obvious immunocompromising disease or treatmen...Continue Reading

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Citations

Oct 10, 2019·The New England Journal of Medicine·Allan R TunkelMaria Martinez-Lage
Sep 5, 2020·Viruses·Abigail L Atkinson, Walter J Atwood
Dec 6, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Fabrizio Di MaidaAndrea Minervini
Jan 31, 2021·Journal of Neurology·Damien Roos-WeilValérie Pourcher
Nov 11, 2020·La Revue de médecine interne·A Moulignier, A Lecler
May 28, 2021·Neurology. Neuroimmunology and Neuroinflammation·Martijn BeudelMatthijs Brouwer
Nov 4, 2021·Neurology. Neuroimmunology and Neuroinflammation·Raphael Bernard-ValnetGuillaume Martin-Blondel

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Methods Mentioned

BETA
biopsy
PCR
biopsies

Software Mentioned

SPSS

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