The incidence and sites of Nasopharyngeal carcinoma (NPC) metastases on FDG PET/CT scans

Oral Oncology
Ammad Shanoon Al TamimiSaabry Osmany

Abstract

The only investigation to determine if a whole body FDG PET/CT scan is helpful in the evaluation of NPC is a study from Stanford. In this study, 26 patients with whole body PET/CT, were evaluated for lesions below adrenals and showed that 7.7% of distant metastases were below adrenals. Our study comparing distant metastases below diaphragm with Stanford study to evaluate the need for whole body PET/CT. Reports of NPC patients in Singapore General Hospital were reviewed. The lesions were analyzed for total number and number below diaphragm. The lesions below the diaphragm were further analyzed if they were solitary or involved multiple areas and if any additional lesions were above diaphragm. 717 reports were included in final analysis. The number of FDG avid lesions in these reports was 709. Distant metastases represented 352 of the 709 lesions. The number of lesions below diaphragm was 152, of the lesions below diaphragm only 16 of lesions have no co-existing distant metastases above diaphragm. From these lesions, there were only 12 solitary lesions. The other 4 has concurrent metastases but all localized below diaphragm. Compared to Stanford study, number of reports is more representative in this study and the yield is much l...Continue Reading

References

May 14, 2005·International Journal of Radiation Oncology, Biology, Physics·Joseph Tung-Chieh ChangShu-Hang Ng
Feb 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Feng-Yuan LiuTzu-Chen Yen
Sep 18, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Feng-Yuan LiuTzu-Chen Yen
Dec 17, 2009·Archives of Internal Medicine·Rebecca Smith-BindmanDiana L Miglioretti
May 25, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Andrei IagaruSanjiv Sam Gambhir

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Citations

Jul 17, 2016·World Journal of Surgical Oncology·Pietro GenovaNicola de'Angelis
May 30, 2020·Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale·Paolo PisaniAngelo Zigliani

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