The incidence, characteristics, and presentation of dengue virus infections during infancy.

The American Journal of Tropical Medicine and Hygiene
Rosario Z CapedingDaniel H Libraty

Abstract

Infants are a vulnerable and unique population at risk for dengue in endemic areas. This report describes the incidence and presenting clinical features of infant dengue virus (DENV) infections from a prospective community-based study performed between January 2007 and May 2009 in the Philippines. DENV3 was the predominant infecting serotype over a wide spectrum of disease severity, ranging from inapparent infection to dengue hemorrhagic fever (DHF). In 2007, the incidence of inapparent DENV infections during infancy was 103 per 1,000 persons person-years and 6-fold higher than symptomatic dengue. The age-specific incidence of infant DHF was 0.5 per 1,000 persons over the age of 3-8 months, and it disappeared by age 9 months. A febrile seizure, macular rash, petechiae, and lower platelet count were presenting clinical features associated with DENV infection among infants with acute undifferentiated febrile illnesses. Community-based studies can help to delineate the incidence rates, disease spectrum, and clinical features of DENV infections during infancy.

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Citations

Jun 23, 2010·Viral Immunology·Alison D AugustinePatricia M Repik
May 10, 2011·The Pediatric Infectious Disease Journal·Krisana PengsaaArunee Sabchareon
Jun 29, 2010·Current Opinion in Infectious Diseases·Lin H Chen, Mary E Wilson
Feb 1, 2012·PLoS Neglected Tropical Diseases·Philippe DussartPedro Fernando da Costa Vasconcelos
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Apr 27, 2016·Jornal de pediatria·Sheila Moura PonePatricia Brasil
Nov 7, 2014·PLoS Neglected Tropical Diseases·Lulu BravoMaïna L'Azou
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Dec 30, 2015·The American Journal of Tropical Medicine and Hygiene·Anne M HauseKay M Tomashek
Dec 17, 2014·The American Journal of Tropical Medicine and Hygiene·Frances E EdilloDonald S Shepard
Jul 4, 2017·PLoS Neglected Tropical Diseases·Luis Mier-Y-Teran-RomeroMichael A Johansson
Apr 26, 2019·PLoS Neglected Tropical Diseases·Kristal An AgrupisJacqueline Deen
Feb 18, 2020·International Journal of Immunogenetics·Renata Duarte da Silva CezarVanessa Gabryelle da Silva Teixeira
Jan 30, 2020·Bulletin of Mathematical Biology·Mostafa AdimyCláudia P Ferreira

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