The incidence, mutational status, risk classification and referral pattern of gastro-intestinal stromal tumours in the Netherlands: a nationwide pathology registry (PALGA) study

Virchows Archiv : an International Journal of Pathology
Arie J VerschoorH Gelderblom

Abstract

Symptomatic gastrointestinal stromal tumours (GIST) are infrequent with an incidence of 12.7 per million inhabitants in the western population. We studied whether the incidence of GIST has further increased between 2003 and 2012 and assessed the frequency of mutations, risk groups, histological subtypes and immunohistochemistry results. From PALGA, the nationwide Dutch Pathology Registry, pathology excerpts from all patients with a GIST or GIST-like tumour between 2003 and 2012 were retrieved to calculate incidence rates. Full pathology reports were retrieved of resections in 2011 and 2012 to study the frequency of mutations, risk groups, histological subtypes and immunohistochemistry results. The incidence of GIST increased to 17.7 per million inhabitants in 2012 with a median age of 67 years. Mutational analysis was performed in 33.9% of patients with a resection between 2011 and 2012 (KIT mutation 67.5%, PDGFRA 16.3%, wild-type 11.4%). The percentage of high risk patients in the different risk classifications varied from 19.9% to 38.0% depending on the used classification. Only 35.9% of patients had diagnosis or revision of pathology diagnosis within three months in a designated GIST referral centre. No increase in proportio...Continue Reading

References

Feb 24, 2001·Journal of Clinical Pathology·J F Graadt van RoggenP C Hogendoorn
Jul 3, 2002·Human Pathology·Christopher D M FletcherSharon W Weiss
Jul 3, 2002·Human Pathology·Markku MiettinenJerzy Lasota
Aug 16, 2002·The New England Journal of Medicine·George D DemetriHeikki Joensuu
Sep 6, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J VerweijO S Nielsen
Jun 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher L CorlessMichael C Heinrich
Nov 19, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Wim G GoettschPancras C W Hogendoorn
Apr 21, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Maria Debiec-RychterUNKNOWN Australasian GastroIntestinal Trials Group
May 9, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P G CasaliUNKNOWN ESMO Guidelines Working Group
Jul 26, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Raf SciotUNKNOWN Australasian Trials Group
Jun 29, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P G CasaliUNKNOWN ESMO/CONTICANET/EUROBONET Consensus Panel of Experts
Dec 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Katherine A JanewayConstantine A Stratakis
Jan 11, 2012·Archives of Pathology & Laboratory Medicine·Andrea MarrariJason L Hornick
Mar 29, 2012·JAMA : the Journal of the American Medical Association·Heikki JoensuuPeter Reichardt
May 16, 2012·Expert Review of Anticancer Therapy·Peter ReichardtAlessandro Gronchi
Jun 22, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Philippe A CassierUNKNOWN European Organisation for Research and Treatment of Cancer
Jun 14, 2013·Annals of Surgical Oncology·Piotr RutkowskiFrits van Coevorden
Mar 19, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher L CorlessRonald P DeMatteo
Sep 12, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·UNKNOWN ESMO/European Sarcoma Network Working Group
Oct 4, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Grace L MaJason K Sicklick
May 15, 2015·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Jan M van der ZwanSabine Siesling
May 24, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Audrey H ChoiJoseph Kim

❮ Previous
Next ❯

Citations

Feb 2, 2018·International Journal of Molecular Sciences·Juozas Kupcinskas
Apr 18, 2018·The British Journal of Surgery·W T A van der GraafJ H W de Wilt
Jun 17, 2020·Tumori·Francesco CuccaroVincenzo Coviello
Jul 5, 2019·Virchows Archiv : an International Journal of Pathology·J E M SwillensR P M G Hermens
Aug 24, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·John GlodBrigitte C Widemann
Mar 20, 2021·Nature Reviews. Disease Primers·Jean-Yves BlayMargaret von Mehren
Apr 26, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Mahmoud MohammadiYvonne Schrage
Apr 29, 2021·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Elisabeth M P SteeghsMarjolijn J L Ligtenberg

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection

Software Mentioned

PALGA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Wim G GoettschPancras C W Hogendoorn
Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Ying-Yong HouAndrea Frilling
Annals of Oncology : Official Journal of the European Society for Medical Oncology
P G CasaliESMO/CONTICANET/EUROBONET Consensus Panel of Experts
Revista médica de Chile
Pablo Bórquez M
© 2022 Meta ULC. All rights reserved