The incidence of analgesics intolerance in asthmatic children detected by history and inhalation challenge with lysine acetylsalicylate

Klinische Pädiatrie
A Hussein

Abstract

To determine the incidence of adverse reactions to analgesics in unselected asthmatic children, histories were obtained from 486 children, using questionnaires and interviews. Mean age was 11.4 +/- 2.3 (+/- 1 SD) years (range 6-17 years), and mean duration of disease was 7.6 +/- 3.6 (1-15) years. The majority of 21 children gave an equivocal history, and only 7 (1.4%) of all children had a reliable history of adverse reactions to various analgesics. Inhalation challenge with increasing doses of lysine acetylsalicylate (LASA) was performed in 75 randomly selected asymptomatic children. Two boys of these (2.7%) had a positive test, defined as a 25% or more decrease of FEV1 and/or a 50% or more increase of the oscillatory airway resistance, compared with base line values. Both children had a mild airway obstruction, and had no personal or family history of analgesics intolerance. Further 27 children with suspected positive personal or family histories were also challenged. One girl of these manifested a mild urticaria; her pulmonary function remained unchanged. The incidence of analgesics intolerance in unselected asthmatic children is much lower than that of 12.5% to 28% reported in severe chronic asthma. The inhalation challenge...Continue Reading

Citations

Sep 28, 1999·Trends in Pharmacological Sciences·M Racchi, S Govoni
Aug 13, 2004·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Mario Sánchez-BorgesFernan Caballero-Fonseca
Oct 26, 2016·The World Allergy Organization Journal·Marek L KowalskiTorsten Zuberbier
Sep 9, 2018·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ozlem CavkaytarDavide Caimmi

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