The incidence of Cushing's disease: a nationwide Swedish study

Pituitary
Oskar RagnarssonGudmundur Johannsson

Abstract

Studies on the incidence of Cushing's disease (CD) are few and usually limited by a small number of patients. The aim of this study was to assess the annual incidence in a nationwide cohort of patients with presumed CD in Sweden. Patients registered with a diagnostic code for Cushing's syndrome (CS) or CD, between 1987 and 2013 were identified in the Swedish National Patient Registry. The CD diagnosis was validated by reviewing clinical, biochemical, imaging, and histopathological data. Of 1317 patients identified, 534 (41%) had confirmed CD. One-hundred-and-fifty-six (12%) patients had other forms of CS, 41 (3%) had probable but unconfirmed CD, and 334 (25%) had diagnoses unrelated to CS. The mean (95% confidence interval) annual incidence between 1987 and 2013 of confirmed CD was 1.6 (1.4-1.8) cases per million. 1987-1995, 1996-2004, and 2005-2013, the mean annual incidence was 1.5 (1.1-1.8), 1.4 (1.0-1.7) and 2.0 (1.7-2.3) cases per million, respectively. During the last time period the incidence was higher than during the first and second time periods (P < 0.05). The incidence of CD in Sweden (1.6 cases per million) is in agreement with most previous reports. A higher incidence between 2005 and 2013 compared to 1987-2004 wa...Continue Reading

References

Apr 1, 1994·Clinical Endocrinology·J Etxabe, J A Vazquez
Jun 11, 1999·Journal of Internal Medicine·L PikkarainenA Reunanen
Jun 12, 1999·Annals of Internal Medicine·B SwearingenN T Zervas
Aug 26, 1999·Rheumatology·C TuressonU Bergström
Dec 21, 2000·International Journal of Cardiology·A LinnersjöC Reuterwall
Mar 7, 2001·The Journal of Clinical Endocrinology and Metabolism·J LindholmJ Weeke
Dec 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Gary D HammerCharles B Wilson
Sep 14, 2006·The Journal of Clinical Endocrinology and Metabolism·Ragnhildur BergthorsdottirGudmundur Johannsson
Jun 11, 2010·The Journal of Clinical Endocrinology and Metabolism·Antti RaappanaTapio Pirilä
Jan 5, 2011·The Journal of Clinical Endocrinology and Metabolism·R N ClaytonP W Jones
May 26, 2011·Clinical Endocrinology·Mark J BollandRobyn J Toomath
Jun 11, 2011·BMC Public Health·Jonas F LudvigssonPetra Otterblad Olausson
Jan 27, 2012·The Journal of Clinical Endocrinology and Metabolism·Zaki K Hassan-SmithPaul M Stewart
Sep 3, 2013·European Journal of Endocrinology·G NtaliN Karavitaki
Aug 3, 2014·European Journal of Endocrinology·Axel TjörnstrandHelena Filipsson Nyström
Nov 7, 2014·The Journal of Clinical Endocrinology and Metabolism·Daniel S OlssonGudmundur Johannsson
May 7, 2015·The Journal of Clinical Endocrinology and Metabolism·Daniel S OlssonEva Andersson

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Citations

May 17, 2019·Clinical Endocrinology·Sofie WenganderOskar Ragnarsson
Mar 5, 2020·The New England Journal of Medicine·Shlomo Melmed
Mar 7, 2020·The Journal of Clinical Endocrinology and Metabolism·Brandon P GalmNicholas A Tritos
May 22, 2020·The Journal of Clinical Endocrinology and Metabolism·Eleni PapakokkinouOskar Ragnarsson
Mar 4, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Pediredla KarunakarBiswajit Dubashi
Nov 5, 2019·Journal of Neuro-oncology·Adomas BuneviciusJason Sheehan
Oct 8, 2020·Reviews in Endocrine & Metabolic Disorders·Valentina GuarnottaCarla Giordano
Jan 2, 2021·Scientific Reports·Tomas FaresjöElvar Theodorsson
Jan 31, 2021·Reviews in Endocrine & Metabolic Disorders·Rosario FerrignoMartin O Savage
Feb 13, 2021·Frontiers in Endocrinology·Mengqi ChangRenzhi Wang
Jul 10, 2020·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Georgia NtaliNiki Karavitaki
Mar 3, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Arza RossetKaren Tordjman
Feb 11, 2021·The Journal of Clinical Endocrinology and Metabolism·Daniel BengtssonJeanette Wahlberg
Mar 25, 2021·Best Practice & Research. Clinical Endocrinology & Metabolism·Stephan Petersenn
Mar 27, 2021·Best Practice & Research. Clinical Endocrinology & Metabolism·Osamah A HakamiNiki Karavitaki
May 12, 2021·The Journal of Clinical Endocrinology and Metabolism·Eleftheria GkaniatsaOskar Ragnarsson

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