The Incidence of Depression in Patients With Diabetic Foot Ulcers: A Systematic Review and Meta-Analysis

The International Journal of Lower Extremity Wounds
Fu-Hui JiangHong-Lin Chen

Abstract

Some patients with diabetic foot ulcers (DFUs) may suffer from depression, but the latest information regarding the incidence of depression in patients with DFUs is limited. This review aimed to provide up-to-date information concerning the incidence of depression in patients with DFUs. We searched the literature in PubMed and Web of Science databases, limited to English publications. 11 eligible studies with a total of 2117 participants were included in this review. A random-effects model was applied due to high heterogeneity. The incidence of depression in patients with DFUs ranged from 26% (95% confidence interval [CI] = 19% to 33%) to 85% (95% CI = 78% to 92%), and was 47% (95% CI = 36% to 58%) after systematically summarizing. Subgroup analyses suggested that the incidence of depression were 49% (95%CI = 35% to 63%) in Europe, 37% (95% CI = 23% to 51%) in Asia, 62% (95% CI = 48% to 76%) in North America. Additionally, the incidence of depression were 40% (95% CI = 29% to 50%) in prospective studies, 55% (95% CI = 28% to 82%) in retrospective studies, 40% (95% CI = 29% to 50%) in cross-sectional studies. Furthermore, the incidence of depression were 43% (95% CI = 25% to 60%), 49% (95% CI = 35% to 63%), 68% (95% CI = 35% to ...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Dec 13, 2000·Journal of Diabetes and Its Complications·G Ragnarson Tennvall, J Apelqvist
Nov 23, 2006·International Journal of Nursing Studies·Yu-Ling BaiHing-Chung Lam
Mar 19, 2008·Journal of the American Podiatric Medical Association·Matteo MonamiEdoardo Mannucci
Apr 5, 2011·Behavioural Brain Research·Claudia A GrilloLawrence P Reagan
Feb 1, 2012·Diabetes/metabolism Research and Reviews·Finn Gottrup, Jan Apelqvist
Jun 14, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·V SiersmaN C Schaper
Feb 16, 2015·Foot and Ankle Surgery : Official Journal of the European Society of Foot and Ankle Surgeons·Christopher HobanElly Trepman
Mar 15, 2015·Journal of Wound Care·A M Reyzelman, I Bazarov
Jun 8, 2015·International Journal of Epidemiology·Jack BowdenStephen Burgess
Jun 17, 2015·Journal of Wound Care·Eric J LewDavid G Armstrong
Jun 18, 2015·Iranian Red Crescent Medical Journal·Firooze DerakhshanpourKamal Mirkarimi
Dec 19, 2015·International Journal of Psychiatry in Medicine·Mohammad G SehloHasan A Alzahrani
Jun 15, 2016·International Journal of Molecular Sciences·Maren Volmer-Thole, Ralf Lobmann
Dec 21, 2016·Journal of Diabetes and Its Complications·Meghan B BrennanChristopher Crnich
Apr 12, 2017·Disability and Health Journal·Susana PedrasM Graça Pereira
Jun 15, 2017·The New England Journal of Medicine·David G ArmstrongSicco A Bus
Jan 19, 2018·Therapeutic Advances in Endocrinology and Metabolism·Alok RaghavBrijesh Kumar Mishra
Jun 14, 2018·Diabetic Medicine : a Journal of the British Diabetic Association·C B SchmidtA Honig
Dec 20, 2018·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Saneh KhunkaewJenny Sim
Jan 20, 2019·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Man-Li ZhaHong-Lin Chen
Mar 7, 2019·Frontiers in Psychiatry·Natalia de M Lyra E SilvaFernanda G De Felice
Nov 19, 2019·European Journal of Internal Medicine·Joana RigorMatilde Monteiro-Soares
Dec 19, 2019·Diabetes/metabolism Research and Reviews·Loretta VileikyteJeffrey S Gonzalez
Jan 8, 2020·Diabetes/metabolism Research and Reviews·Bijan NajafiDavid G Armstrong
Jan 25, 2020·The International Journal of Lower Extremity Wounds·Maria PolikandriotiGeorgia Toulia
Apr 22, 2020·Diabetic Medicine : a Journal of the British Diabetic Association·M WestbyN Cullum

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Citations

Oct 27, 2020·Journal of Mental Health·Susana PedrasM Graça Pereira
Jul 3, 2021·Journal of Clinical Medicine·Ranita SiruEmma J Hamilton

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