The incidence rate of HIV type-1 drug resistance in patients on antiretroviral therapy: a nationwide population-based Danish cohort study 1999-2005

Antiviral Therapy
Anne Margrethe AudelinLouise Bruun Jørgensen

Abstract

Newer antiretroviral treatment regimens for HIV carry a lower risk of inducing drug resistance mutations. We estimated changes in incidence rates (IRs) of new mutations in HIV-infected individuals receiving highly active antiretroviral therapy (HAART). Population-based data were obtained from the Danish HIV Cohort Study and the Danish HIV Sequence Database. We included treatment-naive patients initiating HAART after December 1997 and computed time to first drug resistance mutation, identified as new mutations detected within 1 year after a 60-day period of treatment failure (HIV RNA>1,000 copies/ml). We estimated annual IRs of new resistance mutations towards nucleoside reverse transcriptase inhibitors (NRTIs), non-NRTIs (NNRTIs) and protease inhibitors (PI), and of new specific resistance mutations. A total of 1,829 individuals were observed for 7,294 person-years at risk (PYR). The IR of NRTI resistance decreased from 13.1 per 1,000 PYR (95% confidence interval [CI] 4.9-35.0) in 1999 to 3.7 (1.9-7.2) in 2004-2005 (test for trend P=0.024). The IR of NNRTI resistance decreased from 15.4 (2.2-109.6) in 1999 to 7.9 (4.6-13.6) in 2004-2005 (P=0.077). The IR of PI resistance decreased from 7.5 (1.4-21.8) in 1999 to 2.9 (0.7-11.4) i...Continue Reading

Citations

May 14, 2011·AIDS Research and Human Retroviruses·Anne Margrethe AudelinLouise Bruun Jørgensen
Nov 8, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Viktor von WylUNKNOWN Swiss HIV Cohort Study
Mar 12, 2011·The Journal of Antimicrobial Chemotherapy·Wendy P BannisterUNKNOWN EuroSIDA group
Nov 24, 2011·PloS One·Santiago Avila-RíosUNKNOWN Mexican HIV Molecular Epidemiology Project Group
Dec 30, 2015·The Journal of Infection·German A ContrerasGloria P Heresi
Feb 11, 2011·British Journal of Clinical Pharmacology·Tonny S PetersenNiels Obel
Oct 14, 2017·The Journal of Infectious Diseases·Anna ZhukovaDeenan Pillay
Oct 16, 2020·AIDS·Kristina L BajemaUNKNOWN Centers for AIDS Research Clinical Network of Integrated Systems (CNICS)
Nov 27, 2021·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Maarten van WijheJannik Fonager

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