Abstract
Patients with Luminal A breast cancer often have favorable prognosis, but some of these patients still have lymph node metastases, it remains unclear what the role of adjuvant chemotherapy is in Luminal A subtype with lymph node metastases. The aim of this study was to find a new method to distinguish which Luminal A patient can be benefited from chemotherapy. We retrospectively investigated the inconsistency of molecular subtypes between primary foci and metastatic axillary lymph nodes in Luminal A breast cancer patients, and analyzed the clinicopathologic characteristics, Recurrence score (RS), disease-free survival (DFS), and overall survival (OS) in 146 Luminal A breast cancer patients. The discordance of molecular subtypes between primary foci and metastatic lymph nodes were explored by univariate and multivariate logistic regression. The DFS and OS were calculated by the Kaplan-Meier survival curves, and the Cox regression analyses were performed to identify independent prognostic factors for DFS and OS. In our results, the inconsistency was found in 55 patients (55/146, 37.67 %). Lymphatic vascular invasion (OR 6.402, 95 % CI 2.371-17.287, P < 0.001), lymph node stage (OR 2.147, 95 % CI 1.095-4.209, P = 0.026), and histo...Continue Reading
References
Nov 1, 1991·Histopathology·C W Elston, I O Ellis
Jul 24, 2003·The Surgical Clinics of North America·S Eva SingletaryFrederick L Greene
May 17, 2005·Lancet·UNKNOWN Early Breast Cancer Trialists' Collaborative Group (EBCTCG)
Aug 15, 2006·Breast Cancer Research and Treatment·Lurdes TorresManuel R Teixeira
Mar 21, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C SimmonsM J Clemons
Jun 29, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F CardosoUNKNOWN ESMO Guidelines Working Group
Jan 12, 2011·Breast Cancer Research and Treatment·Gong TangNorman Wolmark
Mar 18, 2011·The Breast Journal·Bing SunSan-Tai Song
Jun 29, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
Jan 24, 2012·The Oncologist·Robyn MacfarlaneStephen K Chia
Mar 9, 2012·The New England Journal of Medicine·Marco GerlingerCharles Swanton
Mar 29, 2013·Annals of Surgical Oncology·Pim J M DingsJohannes H W de Wilt
Jun 29, 2013·Breast Cancer Research and Treatment·Anna-Karin FalckLisa Rydén
Aug 7, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
Sep 7, 2014·American Journal of Surgery·Guo-Shiou LiaoJyh-Cherng Yu
Citations
Dec 1, 2018·Breast Care·Florentia PeintingerCornelia Liedtke
Dec 4, 2020·World Journal of Surgical Oncology·Yilun Li, Li Ma
Aug 30, 2021·BMC Cancer·Yilun Li, Li Ma