The inconvenience of convenience cohorts: rhabdomyosarcoma and the PAX-FOXO1 biomarker.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Abby R RosenbergDouglas S Hawkins

Abstract

"Convenience cohorts" comprise individuals thought to represent the general population, but chosen because they are readily available for evaluation, rather than at random. As such, these methods are subject to bias and may be misleading. Convenience cohorts have been used to investigate the prognostic significance of chromosomal translocations between the PAX3 or PAX7 and the FOXO1 genes in rhabdomyosarcoma, the most common pediatric sarcoma. However, retrospective studies assessing the role of PAX-FOXO1 translocations have yielded inconsistent results. This review highlights the findings from several clinical correlation studies of the PAX-FOXO1 biomarker and illustrates the challenges of using such methods to draw clinical conclusions.

References

Nov 1, 1991·Genes, Chromosomes & Cancer·J A BiegelB S Emanuel
Nov 1, 1991·Genes, Chromosomes & Cancer·E C DouglassH M Maurer
Mar 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W CristR Heyn
Jan 1, 1993·Medical and Pediatric Oncology·E C DouglassD M Parham
May 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K M KellyF G Barr
May 7, 1998·The International Journal of Biochemistry & Cell Biology·F G Barr
Jun 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K S BakerW M Crist
Jun 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W M CristS S Donaldson
Sep 15, 2001·British Journal of Cancer·J AndersonUNKNOWN UK Children's Cancer Study Group (UKCCSG) and the UK Cancer Cytogenetics Group
Jun 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Poul H B SorensenFrederic G Barr
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John C BrenemanWilliam M Crist
Aug 22, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jane L MezaUNKNOWN Children's Oncology Group
May 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Odile OberlinJames R Anderson
Mar 31, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leonard H Wexler, Marc Ladanyi
Mar 31, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel WilliamsonOlivier Delattre
Aug 11, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James R AndersonTimothy J Triche
Nov 18, 2011·Journal of Cancer Research and Clinical Oncology·Sarah N DumontJonathan C Trent

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Citations

Dec 12, 2013·Current Opinion in Pediatrics·Douglas S HawkinsErin R Rudzinski
Jan 12, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Shuji OginoEdward Giovannucci
Jun 28, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Daniel WilliamsonJanet Shipley
Oct 25, 2013·Cancer Medicine·Sarah N DumontJonathan C Trent
Feb 23, 2018·Virchows Archiv : an International Journal of Pathology·Tobias M DantonelloUNKNOWN Cooperative Weichteilsarkom Studiengruppe (CWS)
May 31, 2019·Seminars in Ophthalmology·Paula Cortes BarrantesThaddeus P Dryja
Jan 11, 2020·Frontiers in Oncology·Celine ChenAnton G Henssen
Apr 1, 2020·The Journal of International Medical Research·Weihua HeRong Zhu
May 30, 2013·American Society of Clinical Oncology Educational Book·Carola A S Arndt
Apr 25, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Theodore W LaetschStephen X Skapek
Jun 29, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leo Mascarenhas

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