The incorporation of strontium and zinc into a calcium-silicon ceramic for bone tissue engineering

Biomaterials
Hala ZreiqatColin R Dunstan

Abstract

In this study we developed novel scaffolds through the controlled substitution and incorporation of strontium and zinc into a calcium-silicon system to form Sr-Hardystonite (Sr-Ca(2)ZnSi(2)O(7), Sr-HT). The physical and biological properties of Sr-HT were compared to Hardystonite (Ca(2)ZnSi(2)O(7)) [HT]. We showed that Sr-HT scaffolds are porous with interconnected porous network (interconnectivity: 99%) and large pore size (300-500 microm) and an overall porosity of 78%, combined with a relatively high compressive strength (2.16+/-0.52 MPa). These properties are essential for enhancing bone ingrowth in load-bearing applications. Sr-HT ceramic scaffolds induced the attachment and differentiation of human bone derived cells (HOB), compared to that for the HT scaffolds. Sr-HT scaffolds enhanced expression of alkaline phosphatase, Runx-2, osteopontin, osteocalcin and bone sialoprotein. The in vivo osteoconductivity of the scaffolds was assessed at 3 and 6 weeks following implantation in tibial bone defects in rats. Histological staining revealed rapid new growth of bone into the pores of the 3D scaffolds with the Sr-HT and HT, relative to the beta-tricalcium phosphate (beta-TCP). In vivo, HT and Sr-HT produced distinct differences...Continue Reading

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Citations

Oct 18, 2011·Journal of Materials Science. Materials in Medicine·Kai LiXuebin Zheng
Aug 31, 2013·Journal of Materials Science. Materials in Medicine·Beena Gopalan MohanAnnie John
Sep 10, 2013·Trends in Biotechnology·Susmita BoseAmit Bandyopadhyay
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Jan 5, 2014·Acta Biomaterialia·Qin ZhangGuoping Chen
May 9, 2015·Nanomedicine·Guocheng WangHala Zreiqat
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Dec 30, 2017·Bone Research·Chengde GaoCijun Shuai
Mar 29, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Mohamed Mahmoud AbdallaJukka Pekka Matinlinna

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