The increase in medial prefrontal glutamate/glutamine concentration during memory encoding is associated with better memory performance and stronger functional connectivity in the human medial prefrontal-thalamus-hippocampus network

Human Brain Mapping
Jan-Willem ThielenIndira Tendolkar

Abstract

The classical model of the declarative memory system describes the hippocampus and its interactions with representational brain areas in posterior neocortex as being essential for the formation of long-term episodic memories. However, new evidence suggests an extension of this classical model by assigning the medial prefrontal cortex (mPFC) a specific, yet not fully defined role in episodic memory. In this study, we utilized 1H magnetic resonance spectroscopy (MRS) and psychophysiological interaction (PPI) analysis to lend further support for the idea of a mnemonic role of the mPFC in humans. By using MRS, we measured mPFC γ-aminobutyric acid (GABA) and glutamate/glutamine (GLx) concentrations before and after volunteers memorized face-name association. We demonstrate that mPFC GLx but not GABA levels increased during the memory task, which appeared to be related to memory performance. Regarding functional connectivity, we used the subsequent memory paradigm and found that the GLx increase was associated with stronger mPFC connectivity to thalamus and hippocampus for associations subsequently recognized with high confidence as opposed to subsequently recognized with low confidence/forgotten. Taken together, we provide new evide...Continue Reading

References

Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·U StaubliG Lynch
Jan 1, 1996·Depression and Anxiety·A Kalueff, D J Nutt
Nov 5, 1998·NMR in Biomedicine·M MescherR Gruetter
Apr 17, 2001·The Behavioral and Brain Sciences·J P Aggleton, M W Brown
Jun 19, 2001·NMR in Biomedicine·L VanhammeS V Huffel
Apr 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Scott D SlotnickJohn Hart
Dec 7, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Ognen A C Petroff
Oct 14, 2005·Journal of Neurophysiology·Anna Floyer-LeaPaul M Matthews
Jan 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·A TakashimaG Fernández
Jul 14, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Basilis Zikopoulos, Helen Barbas
Dec 28, 2010·Neuropharmacology·Dimitri M Kullmann, Karri P Lamsa
May 21, 2011·Learning & Memory·John P AggletonElizabeth Clea Warburton
Mar 9, 2012·Trends in Neurosciences·Marlieke T R van KesterenRichard N Henson
Apr 10, 2012·PloS One·Lars MichelsRuth L O'Gorman
Apr 19, 2012·Cold Spring Harbor Perspectives in Biology·Christian Lüscher, Robert C Malenka
Dec 25, 2012·Neuron·David R EustonBruce L McNaughton
Feb 15, 2013·PloS One·Marlieke T R van KesterenGuillén Fernández
Mar 16, 2013·Science·Wei Xu, Thomas C Südhof
Sep 14, 2013·Current Biology : CB·Alison R Preston, Howard Eichenbaum
Sep 2, 2014·Neuron·Sara M Szczepanski, Robert T Knight
Dec 3, 2014·NeuroImage·Cassandra Sampaio-BaptistaHeidi Johansen-Berg
Feb 6, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joseph D Viviano, Keith A Schneider
Sep 17, 2015·Learning & Memory·Jan-Willem ThielenGuillén Fernández
Jan 15, 2016·Trends in Neurosciences·Simon HanslmayrHoward Bowman
Feb 6, 2016·Scientific Reports·Mohamed L Seghier, Cathy J Price

❮ Previous
Next ❯

Citations

Dec 29, 2020·NeuroImage. Clinical·Sylvie BellevilleUNKNOWN CIMA-Q group

❮ Previous
Next ❯

Methods Mentioned

BETA
proton magnetic resonance

Software Mentioned

SPM8
PROCESS
AAScout
jMRUI
AMARES
REX
MRIcron
MarsBaR
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.