The increased expression of Piezo1 and Piezo2 ion channels in human and mouse bladder carcinoma

Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University
Ebru Önalan EtemTuncay Kuloğlu

Abstract

Piezo1/2, a mechanically activated ion channel, is believed to play an important role in bladder carcinogenesis process. Piezo1/2 expression has not been previously reported in urinary bladder carcinoma, and little is known about its significance in bladder carcinogenesis. In our study, we aimed to evaluate the Piezo1 and Piezo2 expression as developmental in mouse bladder tissue and bladder cancer tissue of mice and humans. The detection of developmental expression was performed on P0-P90 days in bladder tissue of Balb/c strain mice. Mice were divided into bladder cancer (n = 40) and control groups (n = 10). Bladder cancer in mice was created by using N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN). In the study, 60 human subjects were included, whose normal tissues were used as controls. After the histopathological evaluation, the expression of Piezo1/2 genes was examined by reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry in tumor and normal tissues. In developmental period of the mice, Piezo1 expression increased on days 21 and 90, whereas Piezo2 expression increased on day 7 and decreased on day 90 in mouse bladder tissues. There was a significant increase in the expression of Piezo1/2 in both ...Continue Reading

Citations

Jan 20, 2019·Journal of Cellular Biochemistry·Rongxing ShiTao Wang
Jan 23, 2019·Acta Biochimica Et Biophysica Sinica·Pingbo YaoLinxi Chen
Sep 9, 2019·Biophysics Reviews·Pietro RidoneBoris Martinac
Oct 2, 2020·Scientific Reports·Wenjianlong ZhouWang Jia
Aug 15, 2019·Annual Review of Cell and Developmental Biology·Michael Sheetz
Jun 18, 2020·Cancer Management and Research·Shanqiang QuZhicheng Hu
Feb 13, 2021·BioMed Research International·Daxue ZhuXuewen Kang
Dec 4, 2020·International Journal of Molecular Sciences·Pei-Jung LiuChih-Yun Yang
Mar 27, 2021·Molecular Therapy. Nucleic Acids·Biqiang ZhuXiaohua Hou
May 4, 2021·Frontiers in Pharmacology·Jing GuoJianhua Sun
May 19, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jia-Lin Yu, Hai-Yang Liao
Jul 9, 2021·Annual Review of Neuroscience·Ruhma Syeda

❮ Previous
Next ❯

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.