The increment of anti-ORP150 autoantibody in initial stages of atheroma in high-fat diet fed mice

The Journal of Veterinary Medical Science
Tomohiro KobayashiHideki Yanagi

Abstract

Expression of 150 kda oxygen-regulated protein, ORP150, was examined in the atheromatous lesions on aortic valves in high-fat diet fed mice. Immunohistochemical staining revealed that ORP150 was expressed on the surface of plaque and was co-localized with phagocytes bearing Mac-3, a mouse macrophage differentiation antigen. These findings suggest that ORP150 is involved in the development of the atheromatous plaque. Titer of autoantibody against ORP150 was gradually elevated in parallel with the length of period of high-fat diet feeding. These results suggest that the deposition of immunocomplex toward ORP150 antigen is involved in atheromatous plaque progression.

References

May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·S IshibashiM S Brown
Jan 3, 1997·Biochemical and Biophysical Research Communications·J IkedaH Yanagi
Apr 9, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·T BjörnhedenO Wiklund
Feb 16, 2000·Biochemical and Biophysical Research Communications·T KobayashiH Yanagi

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Citations

Mar 15, 2016·Frontiers in Immunology·Daming ZuoXiang-Yang Wang
Jan 26, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·Y NakataniM Matsuhisa
Aug 21, 2007·Journal of Bone and Mineral Metabolism·Makoto HiraoHideki Yoshikawa

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