Abstract
After both oral and intravenous glucose administration, peripheral insulin concentrations are lower in trained compared with untrained humans. Part of this is explained by an adaptation within the β-cell. The insulin secretion rate is higher after oral compared with intravenous glucose administration due to the release of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) enhancing the glucose-induced insulin secretion (the incretin effect). Our aim was to investigate whether GIP or GLP-1 release or the incretin effect was different in trained compared with untrained humans after oral and intravenous glucose administration. A 3½-h oral glucose tolerance test was performed in eleven trained and ten untrained, young, healthy men. On a separate day, an isoglycaemic intravenous glucose infusion was performed matching the individual glucose concentrations obtained during the oral glucose tolerance test. Blood samples for insulin, C-peptide, GIP and GLP-1 analyses were obtained frequently during both tests, and the insulin secretion rate, incretin effect and insulin clearance were calculated. Plasma GIP and GLP-1 concentrations, the incretin effect and the insulin clearance did not differ, and plas...Continue Reading
References
Aug 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·F GyntelbergJ O Holloszy
Jun 1, 1976·The Journal of Physiology·S R BloomW R Sulaiman
Jun 1, 1992·Metabolism: Clinical and Experimental·J M WaltersF P Alford
Jan 1, 1991·The American Journal of Clinical Nutrition·T K NordtB Jakober
Feb 1, 1988·Diabetes·L T ShusterF J Service
Dec 1, 1987·Journal of Applied Physiology·D S KingJ O Holloszy
Jan 1, 1986·Diabetologia·M NauckW Creutzfeldt
Aug 1, 1986·The Journal of Clinical Endocrinology and Metabolism·M A NauckW Creutzfeldt
Jan 1, 1987·The Journal of Clinical Endocrinology and Metabolism·G M ReavenJ B Jaspan
Jan 22, 1970·The New England Journal of Medicine·R RabkinJ A Colwell
Jun 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·D R SealsJ O Holloszy
Jan 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·A WirthG Schlierf
Jan 1, 1981·Acta Physiologica Scandinavica·H GalboJ Vinten
Dec 1, 1982·The Biochemical Journal·J J Holst
Apr 1, 1994·Diabetes·C OrskovJ J Holst
Jan 1, 1996·Journal of Applied Physiology·M D VukovichJ O Holloszy
Aug 1, 1996·Computer Methods and Programs in Biomedicine·R HovorkaM A Young
Oct 30, 1998·Endocrine Reviews·W C DuckworthF G Hamel
Mar 8, 2000·Peptides·B HartmannJ J Holst
Jul 2, 2003·Regulatory Peptides·Tina VilsbøllJens J Holst
Oct 20, 2004·Regulatory Peptides·Michael A NauckJuris J Meier
Jul 5, 2007·American Journal of Physiology. Endocrinology and Metabolism·Juris J MeierMichael A Nauck
Sep 27, 2007·American Journal of Physiology. Endocrinology and Metabolism·Anna KotronenHannele Yki-Järvinen
Oct 12, 2007·Physiological Reviews·Jens Juul Holst
Apr 9, 2009·American Journal of Physiology. Endocrinology and Metabolism·Karen R KellyJohn P Kirwan
Feb 13, 2010·The Journal of Clinical Endocrinology and Metabolism·C MartinsJ E Blundell
May 20, 2011·The Journal of Clinical Endocrinology and Metabolism·Ola LindgrenBo Ahrén
Dec 19, 2012·Medicine and Science in Sports and Exercise·Catia MartinsJohn E Blundell
Aug 28, 2013·European Journal of Applied Physiology·Michael Taulo LundFlemming Dela
Citations
Jan 18, 2014·Acta Physiologica·L Eliasson
Jun 24, 2015·Acta Physiologica·P B Persson
Feb 13, 2018·International Journal of Sport Nutrition and Exercise Metabolism·Linn BøhlerCatia Martins
Oct 12, 2018·Journal of Applied Physiology·Steven K MalinMarc Breton
Jan 11, 2019·Journal of Applied Physiology·Emily M HeistonSteven K Malin
Apr 2, 2016·Journal of Applied Physiology·Emily L KullmanJohn P Kirwan
Jan 11, 2017·European Journal of Nutrition·Anne Grethe SchioldanKjeld Hermansen
Jan 20, 2021·European Journal of Sport Science·Morten HindsøJørn Wulff Helge
Nov 7, 2019·Peptides·Lærke S GasbjergFilip K Knop