The incretin effect does not differ in trained and untrained, young, healthy men

Acta Physiologica
M T LundF Dela

Abstract

After both oral and intravenous glucose administration, peripheral insulin concentrations are lower in trained compared with untrained humans. Part of this is explained by an adaptation within the β-cell. The insulin secretion rate is higher after oral compared with intravenous glucose administration due to the release of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) enhancing the glucose-induced insulin secretion (the incretin effect). Our aim was to investigate whether GIP or GLP-1 release or the incretin effect was different in trained compared with untrained humans after oral and intravenous glucose administration. A 3½-h oral glucose tolerance test was performed in eleven trained and ten untrained, young, healthy men. On a separate day, an isoglycaemic intravenous glucose infusion was performed matching the individual glucose concentrations obtained during the oral glucose tolerance test. Blood samples for insulin, C-peptide, GIP and GLP-1 analyses were obtained frequently during both tests, and the insulin secretion rate, incretin effect and insulin clearance were calculated. Plasma GIP and GLP-1 concentrations, the incretin effect and the insulin clearance did not differ, and plas...Continue Reading

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Citations

Jan 18, 2014·Acta Physiologica·L Eliasson
Jun 24, 2015·Acta Physiologica·P B Persson
Feb 13, 2018·International Journal of Sport Nutrition and Exercise Metabolism·Linn BøhlerCatia Martins
Jan 11, 2019·Journal of Applied Physiology·Emily M HeistonSteven K Malin
Apr 2, 2016·Journal of Applied Physiology·Emily L KullmanJohn P Kirwan

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