The incretin hormones: from scientific discovery to practical therapeutics.

Diabetologia
S Mudaliar, R R Henry

Abstract

The incretins are gut hormones secreted in response to nutrient/carbohydrate ingestion and act on the pancreatic beta cell to amplify glucose-stimulated insulin secretion. Incretin hormone-based treatments for patients with type 2 diabetes represent a major advance in diabetes therapeutics. The ability of the incretin agents (glucagon-like peptide 1 [GLP-1] agonists and dipeptidyl peptidase IV [DPP-4] inhibitors) to improve glycaemia with a low associated risk of hypoglycaemia, together with beneficial/neutral effects on body weight, offers a significant advantage for both patients and treating clinicians. In this edition of 'Then and Now,' it is useful to look back 25 years and reflect upon the developments in this field since Nauck and colleagues published two seminal papers. In 1986 they first documented a reduced incretin effect in patients with type 2 diabetes (Diabetologia 29:46-52), and then in 1993 they demonstrated that, in patients with poorly controlled type 2 diabetes, a single exogenous infusion of an incretin (GLP-1) increased insulin levels in a glucose-dependent manner and normalised fasting hyperglycaemia (Diabetologia 36:741-744). In the ensuing 26 years, progress in the field of incretin hormones has resulted...Continue Reading

References

Jan 1, 1986·Diabetologia·M NauckW Creutzfeldt
Jul 2, 2003·Regulatory Peptides·Kristine MortensenCathrine Orskov
Apr 11, 2008·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·V FonsecaS Dejager
Jul 17, 2008·The Journal of Clinical Endocrinology and Metabolism·Chee W Chia, Josephine M Egan
Jul 8, 2011·The Journal of Clinical Endocrinology and Metabolism·Daniel J DruckerJohn B Buse

❮ Previous
Next ❯

Citations

Oct 29, 2014·The Journal of Endocrinology·Motoyasu SatouHiroyuki Sugimoto
Apr 5, 2016·Indian Journal of Endocrinology and Metabolism·Sanjay KalraOmolara Adetunji
Oct 23, 2013·Journal of Cardiothoracic and Vascular Anesthesia·Benjamin A KohlE Andrew Ochroch
Apr 11, 2013·Annales d'endocrinologie·André J Scheen
Mar 26, 2013·The Veterinary Clinics of North America. Small Animal Practice·Claudia E Reusch, Isabelle Padrutt
Nov 20, 2015·Scientific Reports·Tamara ZietekHannelore Daniel
Nov 10, 2013·Meat Science·Marta GallegoFidel Toldrá
Mar 7, 2014·Clinical Therapeutics·Vivian A Fonseca
Oct 22, 2013·Natural Product Reports·Armin Bauer, Mark Brönstrup
Jan 9, 2021·Obesity Surgery·Guilherme Henrique Peixoto de OliveiraEduardo Guimarães Hourneaux de Moura
Sep 16, 2021·Journal of Obesity & Metabolic Syndrome·Jared RosenbergJoon Young Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.