The incretin pathway as a therapeutic target in diabetic kidney disease: a clinical focus on GLP-1 receptor agonists

Therapeutic Advances in Endocrinology and Metabolism
Michaël J B van BaarDaniël H van Raalte

Abstract

Diabetic kidney disease (DKD) remains the main cause for chronic kidney disease (CKD) and end-stage kidney disease (ESKD) worldwide. Both CKD and ESKD lead to major increases in risk of cardiovascular disease and death in people with diabetes. Despite optimal management of lifestyle, glucose levels and hypertension, residual risk remains high, indicating that additional therapies to mitigate the burden of the disease are desired. In past decades, new treatment options for the management of diabetes have emerged, of which some have showed promising renoprotective potential. This review discusses current understanding of the renal effects of glucagon-like peptide receptor agonists and their potential use in prevention and treatment of DKD.

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Citations

Dec 22, 2019·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·David M WilliamsMarc Evans
Nov 22, 2020·Nature Reviews. Nephrology·Radica Z AlicicKatherine R Tuttle
Oct 20, 2020·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kiran Chintam, Alex R Chang
Jul 31, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Junmin WangGuang Ji
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jared BerndtSok Cheon Pak

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Clinical Trials Mentioned

NCT01455896
NCT01394952
NCT03819153

Software Mentioned

LEADER
Harmony
ELIXA
EXSCEL

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