The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application

Annals of Internal Medicine
Stephen A LauerJustin Lessler

Abstract

A novel human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was identified in China in December 2019. There is limited support for many of its key epidemiologic features, including the incubation period for clinical disease (coronavirus disease 2019 [COVID-19]), which has important implications for surveillance and control activities. To estimate the length of the incubation period of COVID-19 and describe its public health implications. Pooled analysis of confirmed COVID-19 cases reported between 4 January 2020 and 24 February 2020. News reports and press releases from 50 provinces, regions, and countries outside Wuhan, Hubei province, China. Persons with confirmed SARS-CoV-2 infection outside Hubei province, China. Patient demographic characteristics and dates and times of possible exposure, symptom onset, fever onset, and hospitalization. There were 181 confirmed cases with identifiable exposure and symptom onset windows to estimate the incubation period of COVID-19. The median incubation period was estimated to be 5.1 days (95% CI, 4.5 to 5.8 days), and 97.5% of those who develop symptoms will do so within 11.5 days (CI, 8.2 to 15.6 days) of infection. These estimates imply that, under conservat...Continue Reading

References

Apr 28, 2009·The Lancet Infectious Diseases·Justin LesslerDerek A T Cummings
Jul 15, 2009·Statistics in Medicine·Nicholas G ReichRon Brookmeyer
Jan 20, 2018·Scientific Reports·Nicholas G ReichNeil M Vora
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Jan 30, 2020·The New England Journal of Medicine·Qun LiZijian Feng
Feb 1, 2020·The New England Journal of Medicine·Camilla RotheMichael Hoelscher
Feb 6, 2020·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin· Eurosurveillance Editorial Team
Feb 7, 2020·Journal of Medical Virology·Carmine Ceraolo, Federico M Giorgi
Feb 13, 2020·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Jantien A BackerJacco Wallinga
Mar 7, 2020·Bulletin of the World Health Organization·Vasee MoorthySoumya Swaminathan
Apr 21, 2020·Journal of Public Health·Alessandro Miglietta, Miriam Levi

❮ Previous
Next ❯

Citations

Mar 21, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Carlo BasileSandip Mitra
Mar 27, 2020·Journal of Crohn's & Colitis·Gionata FiorinoSilvio Danese
Apr 10, 2020·Head & Neck·Darrin V BannDavid Goldenberg
Apr 7, 2020·International Journal of Paediatric Dentistry·Sreekanth Kumar MallineniJayakumar Jayaraman
Apr 23, 2020·Journal of Medical Microbiology·Timothy J J Inglis
Apr 25, 2020·Head & Neck·Giuseppe Meccariello, Oreste Gallo
Apr 25, 2020·The New England Journal of Medicine·Rajesh T GandhiCarlos Del Rio
Apr 28, 2020·Indian Journal of Pediatrics·Jhuma SankarRakesh Lodha
May 1, 2020·Stroke; a Journal of Cerebral Circulation·Matthew S SmithAaron W Grossman
May 1, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Eric A MeyerowitzMark C Poznansky
Apr 29, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Darrin V BannMeghan N Wilson
Apr 18, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Andrea PadoanMario Plebani
May 13, 2020·International Journal of Environmental Research and Public Health·Hanns MoshammerHans-Peter Hutter
Apr 30, 2020·Journal of Internal Medicine·Giuseppe PascarellaFelice Eugenio Agrò
Apr 2, 2020·ELife·Yinon M Bar-OnRon Milo
May 15, 2020·The Cochrane Database of Systematic Reviews·Sarah J ValkNicole Skoetz
Apr 11, 2020·JAMA : the Journal of the American Medical Association·David M Hartley, Eli N Perencevich
May 23, 2020·Journal of the American Heart Association·Tarek AlsaiedArwa Saidi
May 25, 2020·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Robert Hollinshead LongMarc Charles Plaisance
May 14, 2020·Journal of Clinical Medicine·Kensuke MatsushitaOlivier Morel
May 28, 2020·Journal of Clinical Medicine·Giuseppe De NataleClaudia Troise
Apr 4, 2020·The Journal of Bone and Joint Surgery. American Volume·Christopher VannabouathongMohit Bhandari
May 14, 2020·Journal of Biomolecular Structure & Dynamics·Mohammad Mahdi Nejadi BabadaeiMojtaba Falahati
Apr 30, 2020·Nature Reviews. Immunology·Matthew Zirui TayLisa F P Ng
Apr 10, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Xiaoqing WuXiang Wang
Jun 5, 2020·Journal of Investigative Medicine High Impact Case Reports·Amar S ShahRoyce H Johnson
May 10, 2020·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Liang En WeeBan Hock Tan
May 29, 2020·Journal of Medical Virology·Nevio Cimolai
May 7, 2020·American Journal of Physical Medicine & Rehabilitation·Henry L LewDavid X Cifu
Jun 9, 2020·European Heart Journal·J M PericàsUNKNOWN Hospital Clínic Cardiovascular Infections Study Group
May 31, 2020·Journal of Burn Care & Research : Official Publication of the American Burn Association·Shivangi SahaManeesh Singhal
May 12, 2020·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Yujin WangWeidong Hu
May 30, 2020·Viruses·Nadin YounesGheyath K Nasrallah
Mar 3, 2020·Journal of Medical Virology·Qi Lu, Yuan Shi

❮ Previous
Next ❯

Software Mentioned

coarseDataTools
R Foundation for Statistical Computing
activemonitr
R programming language

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Peng LiJian-Bo Yan
Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
Wei-Hsuan HuangPo-Yu Liu
© 2021 Meta ULC. All rights reserved