The independent correlation between high-density lipoprotein cholesterol and subsequent major adverse coronary events

American Heart Journal
Carol E KoroWilliam M Tierney

Abstract

There is substantial evidence from clinical trials that lowering low-density lipoprotein cholesterol (LDL-C) reduces cardiovascular risk. There is less evidence for the salutatory effects of raising high-density lipoprotein cholesterol (HDL-C). The predictive strength of an initial HDL-C measurement and its change over time for major adverse coronary events is not well understood. We identified a cohort of all 6928 patients in an urban primary care practice who had two or more lipid measurements between January 1985 and December 1997. We used bivariable and multivariable (Cox proportional hazards) techniques to identify independent predictors of subsequent major adverse coronary events (hospitalization for myocardial infarction or acute coronary syndrome) after the second set of lipid measurements. The time between first and second lipid measurements averaged 2.6 years. During a mean of 5.1 +/- 3.2 years of observation after their second lipid measurements, 2167 (31%) patients had an acute coronary event. Patients having events were significantly older, more often white, male, and smokers and more often had antecedent diabetes, hypertension, coronary heart disease, and myocardial infarctions. Adjusting for covariates, a 10-mg/d...Continue Reading

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Citations

Jul 28, 2007·International Journal of Clinical Practice·E Bruckert, B Hansel
Aug 14, 2008·Current Medical Research and Opinion·Jonathan BelseyNigel Hague
Jul 10, 2007·Metabolism: Clinical and Experimental·William J KraemerJeff S Volek
Aug 18, 2006·Current Medical Research and Opinion·Massimo Massi-Benedetti
Mar 25, 2014·Clinical Biochemistry·Amirahmad NejatFarzad Hadaegh
Jul 27, 2007·Journal of Lipid Research·Sonia Dugué-PujolAthina-Despina Kalopissis
Jul 18, 2009·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Marie Therese CooneyUNKNOWN SCORE Investigators

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