The Independent Probabilistic Firing of Transcription Factors: A Paradigm for Clonal Variability in the Zebrafish Retina

Developmental Cell
Henrik BoijeWilliam A Harris

Abstract

Early retinal progenitor cells (RPCs) in vertebrates produce lineages that vary greatly both in terms of cell number and fate composition, yet how this variability is achieved remains unknown. One possibility is that these RPCs are individually distinct and that each gives rise to a unique lineage. Another is that stochastic mechanisms play upon the determinative machinery of equipotent early RPCs to drive clonal variability. Here we show that a simple model, based on the independent firing of key fate-influencing transcription factors, can quantitatively account for the intrinsic clonal variance in the zebrafish retina and predict the distributions of neuronal cell types in clones where one or more of these fates are made unavailable.

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Citations

Mar 17, 2016·Zebrafish·Madelyn MullallyJeffrey M Trimarchi
Aug 4, 2016·Frontiers in Neuroanatomy·Henrik BoijeFinn Hallböök
Dec 17, 2016·Current Opinion in Neurobiology·Anthony M RossiClaude Desplan
Nov 16, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Maria K E BlixtFinn Hallböök
Nov 11, 2017·Clinical and Translational Medicine·Sonya StenfeltHenrik Boije
Feb 23, 2020·Biochemistry. Biokhimii︠a︡·N V BobkovaG T Sukhikh
Aug 5, 2017·Nature Reviews. Neuroscience·Hongkui Zeng, Joshua R Sanes
Jan 30, 2018·Frontiers in Neuroscience·Rana AminiCaren Norden
Jul 17, 2020·Development·Christoph ZechnerCaren Norden
Aug 6, 2019·Developmental Cell·Julia Falo-SanjuanSarah J Bray
Feb 19, 2021·Frontiers in Cell and Developmental Biology·Manuela LahneDavid R Hyde

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Methods Mentioned

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transgenic
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