The Independent Role of Inflammation in Physical Frailty among Older Adults with Mild Cognitive Impairment and Mild-to-Moderate Alzheimer's Disease

The Journal of Nutrition, Health & Aging
Laura TayM S Chong

Abstract

To examine the independent and combined effects of inflammation and endocrine dysregulation on (i) baseline frailty status and (ii) frailty progression at one year, among cognitively impaired community dwelling older adults. Prospective cohort study. Tertiary Memory Clinic. We recruited patients with mild cognitive impairment and mild-moderate Alzheimer's disease. Physical frailty status was assessed at baseline and 1-year. Blood biomarkers of systemic inflammation [interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α)] and anabolic hormones [insulin-like growth factor-1 (IGF-1), dehydroepiandrosterone sulphate (DHEAS)] were measured at baseline and examined in relation to physical frailty status at baseline and progression at 1-year. Each subject was categorized as (i) neither pro-inflammatory nor endocrine deficient, (ii) pro-inflammatory (IL-6 or TNF-α, or both, being in highest quartile) but not endocrine deficient, (iii) endocrine deficient (IGF-1 or DHEAS, or both, being in lowest quartile) but not pro-inflammatory and (iv) both pro-inflammatory and endocrine deficient. Twenty (20.2%) of 99 subjects were physically frail at baseline. There was no association between severity of cognitive impairment and baseline frailty s...Continue Reading

References

Nov 1, 1992·Journal of the American Geriatrics Society·P Barberger-GateauJ F Dartigues
Nov 1, 1991·Clinical Immunology and Immunopathology·T SuzukiE G Engleman
Mar 1, 1991·Stroke; a Journal of Cerebral Circulation·P A WolfW B Kannel
Jan 1, 1985·International Rehabilitation Medicine·D T WadeR Langton Hewer
Mar 14, 2000·International Journal of Geriatric Psychiatry·S SahadevanS P Chan
Oct 14, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·L O WahlundP Scheltens
Jun 2, 2001·Stroke; a Journal of Cerebral Circulation·L O WahlundUNKNOWN European Task Force on Age-Related White Matter Changes
Jan 5, 2002·Neurobiology of Aging·R T PerryR C Go
May 22, 2002·Archives of Internal Medicine·Douglas J WatsonHarry A Guess
Jun 1, 2002·Alzheimer Disease and Associated Disorders·Suresh SahadevanSiew Pang Chan
May 3, 2003·The Journal of Clinical Endocrinology and Metabolism·Anne R CappolaLinda P Fried
Mar 20, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Linda P FriedGerard Anderson
Jun 12, 2004·Current Atherosclerosis Reports·José A Luchsinger, Richard Mayeux
Aug 25, 2005·Alzheimer Disease and Associated Disorders·Wee Shiong LimSuresh Sahadevan
Sep 27, 2005·Journal of the American Geriatrics Society·Takuya WatanabeTakashi Iguchi
Mar 29, 2006·Archives of Internal Medicine·Claudia ThomasChris Power
Jun 9, 2007·Psychosomatic Medicine·Aron S BuchmanDavid A Bennett
Jul 20, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kristine E EnsrudUNKNOWN Study of Osteoporotic Fractures Research Group
Aug 13, 2008·Neurology·Aron S BuchmanDavid A Bennett
Oct 22, 2008·European Journal of Endocrinology·Mikkel AndreassenLars Østergaard Kristensen
Feb 3, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Anne R CappolaLinda P Fried
Mar 3, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Sean X LengLinda P Fried
May 26, 2009·The American Journal of Cardiology·Jonathan AfilaloHoward Bergman
Jul 22, 2009·Journal of Endocrinological Investigation·G ValentiR S Schwartz
Jan 5, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Mikkel AndreassenLars Ostergaard Kristensen
Jan 19, 2010·The Journal of Nutrition, Health & Aging·M ChanT L Tan
Mar 12, 2011·Journal of the American Geriatrics Society·Nader FallahKenneth Rockwood
Jan 13, 2012·The Journal of Nutrition, Health & Aging·M MaggioG P Ceda
Apr 3, 2012·American Journal of Alzheimer's Disease and Other Dementias·Aine M Ní MhaoláinBrian Lawlor
Jun 15, 2013·Journal of the American Medical Directors Association·John E MorleyJeremy Walston
Jul 9, 2013·Ageing Research Reviews·Deirdre A RobertsonRose Anne Kenny
Oct 25, 2013·The Journal of Nutrition, Health & Aging·E KelaiditiUNKNOWN IANA/IAGG
Nov 29, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kayla DarvinSara E Espinoza
Apr 5, 2014·Journal of the American Geriatrics Society·Andrea L MettiJane A Cauley
Aug 20, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Aron S BuchmanDavid A Bennett
Sep 24, 2014·Journal of the American Medical Directors Association·Shu NishiguchiTomoki Aoyama

❮ Previous
Next ❯

Citations

May 26, 2017·The Journal of Nutrition, Health & Aging·M RoppoloE Rabaglietti
Oct 31, 2019·Revista latino-americana de enfermagem·Karen MiyamuraRosalina Aparecida Partezani Rodrigues
Dec 11, 2019·Journal of Cachexia, Sarcopenia and Muscle·Markus S AnkerStephan von Haehling
Aug 11, 2018·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Lindsay WallaceMelissa K Andrew
Apr 7, 2019·Journal of Neuroinflammation·Dawling A Dionisio-SantosM Kerry O'Banion
Jul 11, 2018·Dementia & Neuropsychologia·Isabela Thaís Machado de JesusMarisa Silvana Zazzetta
Apr 28, 2017·The Journal of Nutrition, Health & Aging·M D WirthJ R Hébert
Mar 1, 2019·International Journal of Environmental Research and Public Health·Ruby Yu, Jean Woo
Dec 6, 2018·Revista latino-americana de enfermagem·Rosalina Aparecida Partezani RodriguesJair Lício Ferreira Santos
Jan 31, 2018·The Journal of Nutrition, Health & Aging·B Vellas, J E Morley
Aug 15, 2017·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·T P KliushnikA M Dupin
Feb 12, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Daiene de Morais FabrícioBreno S Diniz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.