The indirect alloresponse impairs the induction but not maintenance of tolerance to MHC class I-disparate allografts.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
M J WeissJ C. Madsen

Abstract

We studied the effects of indirect allorecognition on the induction and maintenance phases of tolerance in miniature swine cotransplanted with heart and kidney allografts. MHC class I-mismatched heart and kidney grafts were cotransplanted in recipients receiving CyA for 12 days. Recipients were unimmunized or immunized with a set of donor-derived or control third-party MHC class I peptides either 21 days prior to transplantation or over 100 days after transplantation. T-cell proliferation, delayed type hypersensitivity reaction (DTH) and antibody production were assessed. All animals injected with donor MHC class I peptides developed potent indirect alloresponses specific to the immunizing peptides. While untreated recipients developed stable tolerance, all animals preimmunized with donor allopeptides rejected kidney-heart transplants acutely. In contrast, when peptide immunization was delayed until over 100 days after kidney-heart transplantation, no effects were observed on graft function or in vitro measures of alloimmunity. Donor peptide immunization prevented tolerance when administered to recipients pre transplantation but did not abrogate tolerance when administered to long-term survivors post transplantation. This sugge...Continue Reading

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Citations

Jun 26, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Kortney A RobinsonGilles Benichou
Apr 21, 2018·Transplantation·Sarah J RosenMark A Hardy
Oct 27, 2017·The Journal of Veterinary Medical Science·Nuttika PastarapateeChollada Buranakarl
Jul 9, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cavit D KantGilles Benichou

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