The indirect antinociceptive mechanism of 15d-PGJ2 on rheumatoid arthritis-induced TMJ inflammatory pain in rats

European Journal of Pain : EJP
M S QuinteiroJ-T Clemente-Napimoga

Abstract

Inflammation of the temporomandibular joint (TMJ) induced by rheumatoid arthritis (RA) have resulted in persistent pain and caused distress to many patients. Considering that not all patients respond to traditional drugs therapy to RA and it has demonstrated that 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) into TMJ has a potential peripheral antinociceptive effect, the aim of this study was to evaluate the peripheral effect of 15d-PGJ2 in RA-induced TMJ inflammatory hypernociception. Antigen-induced arthritis (AIA) was generated in rats with methylated bovine serum albumin (mBSA). RA-induced TMJ hypernociception was assessed by measuring the behavioural nociceptive responses. After behavioural experiments, the animals were terminally anaesthetized and periarticular tissues were removed and homogenized. The supernatants were used to evaluate the levels of tumour necrosis factor (TNF)-α, interleukin (IL)-1β and keratinocyte-derived chemokine (KC) by enzyme-linked immunosorbent assay as well the expression of PKCε and PKA by western blotting analysis. The intra-articular injection of mBSA, but not phosphate buffered saline (control), in immunized rats induced dose- and time-dependent behavioural nociceptive responses in which the ...Continue Reading

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Citations

Jul 13, 2014·European Journal of Pharmacology·Mariana Silva QuinteiroJuliana Trindade Clemente-Napimoga
Jun 4, 2016·Prostaglandins, Leukotrienes, and Essential Fatty Acids·C G MacedoJ T Clemente-Napimoga
May 11, 2020·International Immunopharmacology·Henrique Ballassini AbdallaJuliana Trindade Clemente Napimoga
Jun 4, 2021·Inflammation·Ana Carolina de Figueiredo CostaDelane Viana Gondim

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