The indirect health effects of malaria estimated from health advantages of the sickle cell trait.

Nature Communications
Sophie UyogaThomas N Williams

Abstract

Most estimates of the burden of malaria are based on its direct impacts; however, its true burden is likely to be greater because of its wider effects on overall health. Here we estimate the indirect impact of malaria on children's health in a case-control study, using the sickle cell trait (HbAS), a condition associated with a high degree of specific malaria resistance, as a proxy indicator for an effective intervention. We estimate the odds ratios for HbAS among cases (all children admitted to Kilifi County Hospital during 2000-2004) versus community controls. As expected, HbAS protects strongly against malaria admissions (aOR 0.26; 95%CI 0.22-0.31), but it also protects against other syndromes, including neonatal conditions (aOR 0.79; 0.67-0.93), bacteraemia (aOR 0.69; 0.54-0.88) and severe malnutrition (aOR 0.67; 0.55-0.83). The wider health impacts of malaria should be considered when estimating the potential added benefits of effective malaria interventions.

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Citations

Jan 1, 2020·British Journal of Haematology·Scott HansenJohn M Higgins
Apr 9, 2020·Proceedings of the National Academy of Sciences of the United States of America·Christian N NguetseElizabeth S Egan
Mar 11, 2020·Frontiers in Pediatrics·Dominik OchocinskiNiranjan Kissoon
Apr 3, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Elie NkwabongThéophile Nana Njamen
Feb 24, 2021·Nature Medicine·John Muthii MuriukiSarah H Atkinson

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Methods Mentioned

BETA
electrophoresis

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Stata

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