The indirect role of fibroblast growth factor-8 in defining neurogenic niches of the olfactory/GnRH systems

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Paolo E ForniSusan Wray

Abstract

Bone morphogenic protein-4 (BMP4) and fibroblast growth factor-8 (FGF8) are thought to have opposite roles in defining epithelial versus neurogenic fate in the developing olfactory/vomeronasal system. In particular, FGF8 has been implicated in specification of olfactory and gonadotropin releasing hormone-1 (GnRH) neurons, as well as in controlling olfactory stem cell survival. Using different knock-in mouse lines and Cre-lox-mediated lineage tracing, Fgf8 expression and cell lineage was analyzed in the developing nose in relation to the expression of Bmp4 and its antagonist Noggin (Nog). FGF8 is expressed by cells that acquire an epidermal, respiratory cell fate and not by stem cells that acquire neuronal olfactory or vomeronasal cell fate. Ectodermal and mesenchymal sources of BMP4 control the expression of BMP/TGFβ antagonist Nog, whereas mesenchymal sources of Nog define the neurogenic borders of the olfactory pit. Fgf8 hypomorph mouse models, Fgf8(neo/neo) and Fgf8(neo/null), displayed severe craniofacial defects together with overlapping defects in the olfactory pit including (1) lack of neuronal formation ventrally, where GnRH neurons normally form, and (2) altered expression of Bmp4 and Nog, with Nog ectopically expresse...Continue Reading

References

Jul 27, 1995·Nature·P A Wilson, A Hemmati-Brivanlou
Jan 1, 1995·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·P C Tompach, D L Zeitler
Jan 10, 1997·Cell·A Hemmati-Brivanlou, D Melton
Nov 5, 1997·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·K MølstedN E Skakkebaek
Jul 25, 2000·Journal of Cellular Biochemistry·A E Kearns, M B Demay
Feb 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Elaine E StormGail R Martin
Jan 1, 2004·Genes & Development·Edgar M PeraEddy M De Robertis
Mar 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eva ChmielnickiSteven A Goldman
Dec 14, 2004·Development·Emilie DelauneLaurent Kodjabachian
Feb 16, 2005·Developmental Neuroscience·Shimako KawauchiAnne L Calof
Feb 18, 2005·Development·Wei LiuJames F Martin
Apr 15, 2005·Development·Claudio D Stern
Nov 18, 2005·Cell·Ulrich BoehmLinda B Buck
Feb 2, 2006·The Journal of Cell Biology·Xuan WangElaine Fuchs
Apr 15, 2006·Development·Elaine E StormJohn L R Rubenstein
May 25, 2006·Development·Roger IlaganErik N Meyers
Sep 9, 2006·Endocrine Journal·Tsutomu OgataKenjiro Kosaki
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Bridget M RileyJeffrey C Murray
Feb 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jia Sheng HuEdwin S Monuki
Jul 4, 2008·The Journal of Clinical Investigation·John FalardeauNelly Pitteloud
Mar 20, 2009·Development·Shimako KawauchiAnne L Calof
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Leslie MarchalLaurent Kodjabachian
Apr 15, 2010·Frontiers of Hormone Research·Wilson C J Chung, Pei-San Tsai
May 14, 2010·The Journal of Clinical Endocrinology and Metabolism·Ericka B TrarbachAna Claudia Latronico
Jun 12, 2010·International Journal of Paediatric Dentistry·Isabelle Bailleul-ForestierNicolas de Roux

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Citations

Oct 14, 2014·Frontiers in Neuroendocrinology·Paolo E Forni, Susan Wray
Jun 7, 2016·Experimental Neurology·C Ron Yu, Yunming Wu
Aug 18, 2018·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Lu M Yang, David M Ornitz
May 27, 2020·Journal of Neuroendocrinology·Megan L Linscott, Wilson C J Chung
May 30, 2017·Frontiers in Cell and Developmental Biology·Linda OttoboniGianvito Martino
Mar 19, 2019·Frontiers in Cellular Neuroscience·Ed Zandro M TarocPaolo E Forni
Jul 30, 2019·Frontiers in Cell and Developmental Biology·Hyun-Ju ChoSusan Wray
Nov 17, 2020·Frontiers in Physiology·Ed Zandro M TarocPaolo E Forni
Apr 3, 2021·Development·Aasakiran MadamanchiDavid M Umulis
Apr 20, 2021·Cellular and Molecular Life Sciences : CMLS·Raghu Ram Katreddi, Paolo E Forni
Sep 16, 2020·Molecular and Cellular Endocrinology·Thomas SchmidThomas Braun
Aug 27, 2021·Development·Aasakiran MadamanchiDavid M Umulis
Sep 24, 2021·Journal of Neuroendocrinology·Yufei Shan, Susan Wray

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