The individual and joint contributions of Helicobacter pylori infection and family history to the risk for peptic ulcer disease

The Journal of Infectious Diseases
H BrennerG Adler

Abstract

Family history of peptic ulcer and infection with Helicobacter pylori have been identified as major risk factors for peptic ulcer disease. It is unclear, however, to what degree their impacts are independent of each other. This question was addressed in a cross-sectional study among 299 consecutive out-patients (25-54 years old) of a general practitioner. Adjusted odds ratios (95% confidence intervals) for gastroscopically verified peptic ulcer disease were 3.8 (1.4-10.1) for persons with H. pylori infection, 8.4 (2.9-24.1) for persons with a family history of ulcer, and 29.5 (6.1-143.9) for persons with both risk factors compared with persons without these risk factors. These results suggest strong, multiplicative contributions of both factors to the risk for peptic ulcer disease.

Citations

Aug 12, 2010·The Journal of Infectious Diseases·Guillermo I Perez-PerezMartin J Blaser
Jun 7, 2003·Journal of Clinical Microbiology·Guillermo I Pérez-PérezMartin J Blaser
Jul 27, 1999·Gastroenterology·M RowlandB Drumm
Mar 27, 2002·International Journal of Epidemiology·Susan Levenstein
Oct 29, 2000·The American Journal of Gastroenterology·A KawamuraY Kinoshita
Sep 5, 2001·Clinical and Experimental Immunology·M A Garcia-GonzalezA S Peña

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