PMID: 8972692Sep 1, 1996Paper

The indoor microfungus Trichoderma viride potentiates histamine release from human bronchoalveolar cells

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
F O LarsenS Norn

Abstract

Trichoderma viride (Tv) is often found in damp and mouldy buildings where people complain of adverse health effects including mucosal/respiratory symptoms. Inhaled spores can reach the alveoli and may interact with the airway epithelium. An interaction with the mucosal mast cells was studied in cells obtained by bronchoalveolar lavage (BAL) from 18 individuals. The fungal spores were found to trigger histamine release from the BAL cells, but relatively high concentrations (0.1-2 mg/ml) were needed. A similar dose response was obtained in basophil histamine release. The Tv-induced mediator release was caused by non-immunological (non-IgE-dependent) mechanisms since the histamine release was not changed by removal of IgE from the basophils before exposure of the cells to the spores. However, in very low concentrations (0.1 ng/ml) the fungal spores were found to potentiate IgE-mediated histamine release triggered by anti-IgE antibody in suspensions of BAL cells. Potentiation was also obtained in basophil histamine release, but relatively high concentrations of Tv (10(-2) mg/ ml) were needed. Our in vitro experiments show that mucosal mast cells from the airways are highly sensitive to the potentiating effect of Tv. Although inhala...Continue Reading

References

Mar 1, 1991·The American Review of Respiratory Disease·R E DalesH Zwanenburg
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Mar 1, 1996·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·F O LarsenS Norn

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Citations

Jun 5, 2003·Fungal Genetics and Biology : FG & B·Kristian Fog Nielsen
Dec 2, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·F O LarsenP Clementsen
Feb 11, 2012·Critical Reviews in Immunology·Alasdair M Gilfillan, Michael A Beaven
Apr 11, 2012·Scandinavian Journal of Immunology·Y Romo-LozanoE Salinas
Aug 5, 2003·Acta Microbiologica Et Immunologica Hungarica·L KredicsElisabeth Nagy

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